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Pathological study and transplantation of Bone marrow stromal cell in a model of amyotrophic lateral sclerosis

Research Project

Project/Area Number 20790614
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionTottori University

Principal Investigator

KITAYAMA Michio  Tottori University, 医学部, 助教 (70379650)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsモデルマウス / 筋萎縮性側索硬化症 / 骨髄間質細胞移植
Research Abstract

Histological examination of the transgenic mice tissue at ventral horn using General stain and immunohistochemisity. Although the result is a nerve cell shedding onset after severe would mutant SOD1 are each in nerve cells, aging degenerative in organelle and inclusion bodies in cells had emerged from early. Therapeutic effect of Bone marrow stromal cell transplantation for anterior mice in quality between cell bone marrow, after consideration of clinical and pathological tissue chemically. However, as a result, port group in the life-prolonging effects, and histologically also remained a spinal cord ventral horn cells, but as a clinical effect was not enough.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (20 results)

All 2010 2009 2008

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (12 results)

  • [Journal Article] Assessment of dementia in patients with multiple system atrophy.2009

    • Author(s)
      Kitayama. M
    • Journal Title

      European Journal of Neurology 16

      Pages: 589-594

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of dementia in the rural island town of Ama-cho, Japan.2009

    • Author(s)
      Wada-isoe K.
    • Journal Title

      Neuroepidemiology 32

      Pages: 101-106

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel cell transplantation protocol and its applicati on to an ALS mouse model.2008

    • Author(s)
      Eri Morita, M. Kitavama, et al.
    • Journal Title

      Experimental Neurology. 213

      Pages: 431-438

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adherent Monomer-Misfolded SOD1.2008

    • Author(s)
      Yasuhiro Watanabe, M. Kitavama, et al.
    • Journal Title

      PLoS ONE. 3

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial changes in motor neurons of homozygotesof leucine 126 TT deletion SOD1 transgenic mice.2008

    • Author(s)
      Koji Doi, M.Kitayama, et al.
    • Journal Title

      Neuropathology. 28

      Pages: 269-276

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel cell transplantation protocol and its application to an ALS mouse model2008

    • Author(s)
      Eri Morita
    • Journal Title

      Experimental Neurology 213

      Pages: 431-438

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adherent Monomer-Misfolded SOD12008

    • Author(s)
      Yasuhiro Watanabe
    • Journal Title

      PLoS ONE 3

      Pages: 3497-3497

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial changes in motor neurons of homozygotes of leucine 126 TT deletion SOD1 transgenic mice2008

    • Author(s)
      Koji Doi
    • Journal Title

      Neuropathology 28

      Pages: 269-276

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] パーキンソン病における神経メラニンイメージングとMIBG心筋シンチグラフィーについて2010

    • Author(s)
      北山通朗
    • Organizer
      第51回日本神経学会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] パーキンソン病における神経メラニンイメージングと123I-MIBG心筋シンチグラフィーとの関係について2009

    • Author(s)
      北山通朗
    • Organizer
      日本自律神経学会総会
    • Place of Presentation
      ダイワロイネットホテル和歌山(和歌山)
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] 進行性核上性麻痺における臨床症状とMIBG心筋シンチグラフィーの検討2009

    • Author(s)
      北山通朗
    • Organizer
      MDSJ
    • Place of Presentation
      品川プリンスホテル(東京)
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] MIBG心筋シンチグラフィーの異常を認めた進行性核上性麻痺の一例2009

    • Author(s)
      北山通朗
    • Organizer
      日本神経学会地方会
    • Place of Presentation
      広島国際会議場(広島)
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 進行性核上性麻痺における臨床症状とMIBG心筋シンチグラフィーの検討2009

    • Author(s)
      北山通朗
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Association of visual hallucinations with reduction of MIBG cardiac uptake in Parkinson's disease.2009

    • Author(s)
      Michio Kitavama.
    • Organizer
      The 9th International Conference AD/PD
    • Place of Presentation
      Prague
    • Year and Date
      2009-03-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Association of visual hallucinations with reduction of MIBG cardiac uptake in Parkinson's disease2009

    • Author(s)
      Michio Kitayama
    • Organizer
      the 9th International Conference AD/PD
    • Place of Presentation
      Prague
    • Year and Date
      2009-03-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 進行性核上性麻痺における1231-MIBG心筋シンチグラフィーについて2008

    • Author(s)
      北山通朗
    • Organizer
      日本自律神経学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] CLINICAL EVALUATION OF PARKINSON'S DISEASE DEMENTIA : ASSOCIATION WITH AGING AND VISUAL HALLUCINATION.2008

    • Author(s)
      Michio Kitavama.
    • Organizer
      The 6th International Congress on Mental Dysfunctions & other Non-Motor Features in Parkinson's disease and Related disorders
    • Place of Presentation
      Dresden
    • Year and Date
      2008-10-17
    • Related Report
      2010 Final Research Report
  • [Presentation] CLINICAL EVALUATION OF PARKINSON'S DISEASE DEMENTIA : ASSOCIATION WITH AGING AND VISUAL HALLUCINATION2008

    • Author(s)
      Michio Kitayama
    • Organizer
      The 6th International Congress on Mental Dysfunctions & other Non-Motor Features in Parkinson's disease and Related disorders
    • Place of Presentation
      Dresden
    • Year and Date
      2008-10-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] パーキンソン病におけるMIB6心筋シンチグラフィーの経時的変化について2008

    • Author(s)
      北山通朗
    • Organizer
      MDSJ
    • Place of Presentation
      京都
    • Year and Date
      2008-10-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] パーキンソン病におけるMIB6心筋シンチグラフィーの経時的変化について2008

    • Author(s)
      北山通朗
    • Organizer
      第49回日本神経学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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