ldentification of new target moJecule in autoimmune-mediated polyneuropathy and establ ishment of a disease model
| Project/Area Number |
20790620
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
FUNAKOSHI Kei Dokkyo Medical University, 医学部, 助教 (50406188)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 免疫性ニューロパチー / 自己抗体 / 標的分子 |
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| Research Abstract |
We analyzed 46 serum samples from neuropathy patients with IgM M protein for anti-glycolipid antibody testing. Serum IgM antibodies against GDlb and SGPG were measured by ELISA. We searched for a new IgM antibody to human brain protein by Western blot. Five were positive for anti-GDlb IgM antibody and 30 for anti-SGPG. Among 13 negative for anti-GDlb and anti-SGPG IgM antibody, 4 were positive for 40 kDa protein. This antibody more frequently was detected in neuropathy patients with IgM M protein than in each neurological disease control. We suggest that the 40kDa protein could be a target molecule for specific autoantibody in neuropathy with IgM M protein.
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Report
(3 results)
Research Products
(24 results)
