ldentification of new target moJecule in autoimmune-mediated polyneuropathy and establ ishment of a disease model

• Project/Area Number: 20790620
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: Dokkyo Medical University
• Principal Investigator: FUNAKOSHI Kei Dokkyo Medical University, 医学部, 助教 (50406188)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 免疫性ニューロパチー / 自己抗体 / 標的分子

Research Abstract

We analyzed 46 serum samples from neuropathy patients with IgM M protein for anti-glycolipid antibody testing. Serum IgM antibodies against GDlb and SGPG were measured by ELISA. We searched for a new IgM antibody to human brain protein by Western blot. Five were positive for anti-GDlb IgM antibody and 30 for anti-SGPG. Among 13 negative for anti-GDlb and anti-SGPG IgM antibody, 4 were positive for 40 kDa protein. This antibody more frequently was detected in neuropathy patients with IgM M protein than in each neurological disease control. We suggest that the 40kDa protein could be a target molecule for specific autoantibody in neuropathy with IgM M protein.

Research Products

• [Journal Article] Acute hand weakness as a regional variant of GuillainTBarre syndrome (2009)
  • Author(s): Galassi G, Glrolami F, Nobile-OrazioE, Funakoshi K, Arlatti A, Odaka M
  • Journal Title: European Journal of Neurology 16巻
  • Peer Reviewed
• [Journal Article] 船越慶-リコブタ-搬送で救命できたGuillain-Barre症候群の1例 (2009)
  • Author(s): 高村-鉱, 吉持厳信, 荒竹トシ子, 中尾紘一, 矢揮省吾
  • Journal Title: 地域医学 23巻 Pages: 782-786
  • Peer Reviewed
• [Journal Article] 盤塵慶, 星加明徳ロタウイルス感染が先行したGuillain-Barre症候群の1女児例 (2009)
  • Author(s): 竹下ちひろ, 山中岳, 菅波佑介, 鈴木一徳, 小穴信吾, 河島尚志, 宮島祐
  • Journal Title: 日本小児科学会誌 113巻 Pages: 1572-1575
  • Peer Reviewed
• [Journal Article] Clinical predictors of mechanical ventilation in Fisher/Guillain-Barre overlap syndrome (2009)
  • Author(s): Funakoshi K, Kuwabara S, Odaka班, Hirata K, Yukl N
  • Journal Title: Journal of Neurology Neurosurgery and Tpsychiatry 80巻 Pages: 60-64
  • Peer Reviewed
• [Journal Article] 萩野谷和裕筋痛を主訴に非典型的な経過をたどりギラン・バレー症候群亜型と考えられた1例小児科臨床 (2009)
  • Author(s): 佐藤育子, 佐藤徹雄, 小野雅典, 桶津圭介, 柿坂庸介, 船越慶
  • Journal Title: 62巻 Pages: 115-118
  • Peer Reviewed
• [Journal Article] Acute hand weakness as a regional variant of Guillain-Barre syudrome. (2009)
  • Author(s): Galassi G, Girolami F, Nobile-OrazioE, Funakoshi K, Ariatti A, Odaka M
  • Journal Title: European Journal of Neumlogy 16
  • Peer Reviewed
• [Journal Article] ヘリコプター搬送で救命できたCruillain-Barre症候群の1例 (2009)
  • Author(s): 高村一鉱, 吉持厳信, 荒竹トシ子, 中尾紘一, 矢澤省吾, 船越慶
  • Journal Title: 地域医学 Pages: 782-786
  • Peer Reviewed
• [Journal Article] ロタウイルス感染が先行したGuillain-Barre症候群の1女児例 (2009)
  • Author(s): 竹下ちひろ, 山中岳, 管波佑介, 鈴木一徳, 小穴信吾, 河島尚志, 宮島祐, 船越慶, 星加明徳
  • Journal Title: 日本小児科学会誌 113 Pages: 1572-1575
  • NAID: 10026276300
  • Peer Reviewed
• [Journal Article] Clinical predictors of mechanical ventilation in Fisher/Guillain-Barre overlap syndrome (2009)
  • Author(s): Funakoshi K, Kuwabara S, Odaka M. Hirata K. Yuki N
  • Journal Title: Journal of Neurology Neurosurgery and Psychiatry 80 Pages: 60-64
  • Peer Reviewed
• [Journal Article] 筋痛を主訴に非典型的な経過をたどりギラン・バレー症候群亜型と考えられた1例 (2009)
  • Author(s): 佐藤育子, 佐藤徹雄, 小野雅典, 涌澤圭介, 柿坂庸介, 船越慶, 萩野谷和裕
  • Journal Title: 小児科臨床 62 Pages: 115-118
  • Peer Reviewed
• [Journal Article] Complement inhibitor prevents disruption of sodium channel clusters ln a rabbit model of Guillain-Barre syndrome (2008)
  • Author(s): Phongsisay V, Susuki K, Matsuno K, Yamahashi T, Okamoto S, Funakoshi K, Hlrata K, Shinoda M, Yukl N
  • Journal Title: Journal of Neuroimmunology 205巻 Pages: 101-104
  • Peer Reviewed
• [Journal Article] Delirium in two patients with Bickerstaff' s brainstem encephalitls (2008)
  • Author(s): Wada Y, Yanagihara C, Nishlmura Y, Funakoshi K, Odaka M
  • Journal Title: Journal of the Neurological Sciences 269巻 Pages: 101-104
  • Peer Reviewed
• [Journal Article] 蝶形骨洞炎の先行感染が示唆されたFisher症候群 (2008)
  • Author(s): 井上博之, 古閑紀雄, 石田春彦, 船越慶, 丹生健一
  • Journal Title: 日本耳鼻咽喉科学会報 111巻 Pages: 628-631
  • NAID: 10024371308
  • Peer Reviewed
• [Journal Article] 重症Guillain-Barre症候群に対する免疫グロブリン大量静注・ステロイド併用療法の検討神経内科 (2008)
  • Author(s): 西田浩, 黒田友基, 脇田賢治, 船越慶, 小鷹昌明
  • Journal Title: 69巻 Pages: 95-98
  • Peer Reviewed
• [Journal Article] Complement inhibitor prevents disruption of sodium channel clusters in a rabbit model of Guillain-Barr6 syndrome (2008)
  • Author(s): Phongsisay V, Susuki K, Matsuno K, Yamahashi T, Okamoto S, Funakoshi K, Hirata K, Shinoda M, Yuki N
  • Journal Title: Journal of Neuroimmunology 205 Pages: 101-104
  • Peer Reviewed
• [Journal Article] Delirium in two patients with Bickerstaff's brainstem encephalitis (2008)
  • Author(s): Wada Y, Yanagihara C, Nishimura Y, Funakoshi K, Odaka M
  • Journal Title: Journal of the Neurological Sciences 269 Pages: 184-186
  • Peer Reviewed
• [Journal Article] 蝶形骨洞炎の先行感染が示唆されたFisher症候群 (2008)
  • Author(s): 井上博之, 古閑紀雄, 石田春彦, 船越慶, 丹生健一
  • Journal Title: 日本耳鼻咽喉科学会報 111 Pages: 628-631
  • NAID: 10024371308
  • Peer Reviewed
• [Journal Article] 重症Guillain-Barre症候群に対する免疫グロブリン大量静注・ステロイド併用療法の検討 (2008)
  • Author(s): 西田浩, 黒田友基, 脇田賢治, 船越慶, 小鷹昌明
  • Journal Title: 神経内科 69 Pages: 95-98
  • Peer Reviewed
• [Presentation] Relationship of ant1-glycolipid complex antlbodles with clinical phenotypes in anti-GQlb lgG antibody syndrome (2009)
  • Author(s): Funakoshi K, Ito M, Kolke S, Hirata K, Yuki N
  • Organizer: Peripheral Nerve Society
  • Place of Presentation: Wtirzburg, Germany
  • Year and Date: 2009-07-06
• [Presentation] Relationship of anti-glycolipid complex antibodies with clinical phenotypes in anti-GQlb IgG antibody syndrome (2009)
  • Author(s): Funakoshi K, Ito M, Koike S, Hirata K, Yuki N
  • Organizer: Peripheral Nerve Society
  • Place of Presentation: Wurzburg, Germany
  • Year and Date: 2009-07-06
• [Presentation] 抗GQlb抗体症候群における抗糖脂質複合体抗体の陽性率の検討 (2009)
  • Author(s): 船越慶, 平田幸一, 結城伸泰
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2009-05-20
• [Presentation] 抗GQ1b抗体症候群における抗糖脂質複合体抗体の陽性率の検討 (2009)
  • Author(s): Wurzburg, Germany船越慶, 平田幸一, 結城伸泰
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2009-05-20
• [Presentation] IgM Mタンパクを伴うニューロパチ一における新規の標的分子探索 (2008)
  • Author(s): 船越慶, 増捌美由紀, 谷中千秋, 平田幸一, 結城伸泰
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16
• [Presentation] IgM Mタンパクを伴うニューロパチーにおける新規の標的分子探索 (2008)
  • Author(s): 船越慶, 増渕美由紀, 谷中千秋、平田幸一, 結城伸泰
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16