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LRRK2 associates with the membrane trafficking system.

Research Project

Project/Area Number 20790624
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionJuntendo University

Principal Investigator

HATANO Taku  Juntendo University, 医学部, 助教 (60338390)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsLRRK2 PARK8 / 家族性パーキンソン病 / 膜輸送 / Exocytosis / LRRK2 / iRNA / PARK8 / exocytosis
Research Abstract

Leucin-rich repeat kinase 2 (LRRK2) is causative protein of PARK8-linked familial Parkinson's disease and associates with the membrane trafficking system. In this study, we have explored whether LRRK2 influences the exocytosis in cultured cells. We revealed that knocking down LRRK2 expression disrupted the exocytosis of growth hormone in PC12 cells, which are rat adrenal pheocromocytoma cell line. However, pathogenic LRRK2 mutants could not influence the exocytosis, compared to wild LRRK2. Therefore, LRRK2 might participate in the membrane trafficking system, but we need further investigations to understand whether pathogenic LRRK2 mutants may affect the functions of exocytosis.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (18 results)

All 2009 2008

All Journal Article (10 results) (of which Peer Reviewed: 7 results) Presentation (8 results)

  • [Journal Article] Pathogenesis of familial Parkinson's disease: New insights based on monogenic forms of Parkinson's disease2009

    • Author(s)
      Hatano T, Kubo S-I, Sato S, Hattori N.
    • Journal Title

      J Neurochem (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fatigue in Japanese patients with Parkinson ' s disease: A study using Parkinson fatigue scale2009

    • Author(s)
      Okuma Y, Kamei S, Morita A, YoshiiF, Yamamoto T, Hashimoto S, Utsumi H, Hatano T, Hattori N, Matsumura M, Takahashi K, Nogawa S, Watanabe Y, Miyamoto T, Miyamoto M, Hirata K.
    • Journal Title

      Mov Disord. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unmet needs of patients with Parkinson's disease: interview survey of patients and caregivers2009

    • Author(s)
      Hatano T, Kubo S-I, Shimo Y, Nishioka K, Hattori N.
    • Journal Title

      J Int Med Res 37(3)

      Pages: 717-726

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Progress in the pathogenesis and genetics of Parkinson ' s disease2008

    • Author(s)
      Mizuno Y, Hattori N, Kubo S-I, Sato S, Nishioka K, Hatano T, Tomiyama H, Funayama M, Machida Y, Mochizuki H.
    • Journal Title

      Philos Trans R Soc Lond B Biol Sci 363(1500)

      Pages: 2215-2227

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] LRRK2 regulates synaptic vesicle endocytosis2008

    • Author(s)
      Shin N, Jeong H, Know J, Heo HY, Know JJ, Yun HJ, Kim CH, Tong Y, Shen J, Hatano T, Hattori N, Kim KS, Chang S, Seol W.
    • Journal Title

      Exp Cell Res 314(10)

      Pages: 2055-2065

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The frequency of cardiac valvular regurgitation in Parkinson's disease2008

    • Author(s)
      Yamashiro K, Komine-Kobayashi M, Hatano T, Urabe T, Mochiuki H, Hattori N, Iwama Y, Daida H, Sakai M, Nakayama T, Mizuno Y.
    • Journal Title

      Mov Disord 23(7)

      Pages: 935-941

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] パーキンソン病を理解するための最新基礎知識(解説/特集)2008

    • Author(s)
      波田野琢
    • Journal Title

      医学のあゆみ 225

      Pages: 460-466

    • Related Report
      2008 Annual Research Report
  • [Journal Article] ミトコンドリアと神経変性疾患2008

    • Author(s)
      波田野琢, 服部信孝
    • Journal Title

      脳と精神の医学 19

      Pages: 81-89

    • NAID

      10026932917

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 家族性パーキンソン病2008

    • Author(s)
      波田野琢, 服部信孝
    • Journal Title

      成人病と生活習慣病 38

      Pages: 893-899

    • Related Report
      2008 Annual Research Report
  • [Journal Article] LRRK2 regulates synaptic vesicle endocytosis2008

    • Author(s)
      Shin N, et.al.
    • Journal Title

      Experimental cell research 314

      Pages: 2055-2065

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] パーキンソン病患者の服薬状況と治療費用について2009

    • Author(s)
      波田野琢, 他
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Presentation] Parkin knockout mouse脳を用いた蛋白質プロファイリング解析2009

    • Author(s)
      今井哲司, 波田野琢, 他
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Presentation] Parkinの放出機構への影響の検討2009

    • Author(s)
      江口博人, 今泉美佳, 近岡洋子, 佐藤栄人, 波田野琢, 他
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Presentation] DJ-1蛋白の細胞膜組織における局在に関する検討2008

    • Author(s)
      波田野琢, 他
    • Organizer
      第27回日本認知症学会
    • Place of Presentation
      前橋
    • Related Report
      2009 Final Research Report
  • [Presentation] パーキンソン病のunmet needs2008

    • Author(s)
      波田野琢, 他
    • Organizer
      第49回日本神経学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Unmet needs of Parkinson's disease patients2008

    • Author(s)
      Taku Hatano
    • Organizer
      The 12^<th> International Congress of Parki nson' s disease and Movement disorders Chicago
    • Place of Presentation
      Chicago
    • Related Report
      2008 Annual Research Report
  • [Presentation] Proteomic analysis of parkin-deficient mice : the possible alteration in protein content in the midbrain2008

    • Author(s)
      Taku Hatano
    • Organizer
      133^<rd> Annual Meeting
    • Place of Presentation
      Salt Lake City
    • Related Report
      2008 Annual Research Report
  • [Presentation] Parkin regulates depolarization-induced exocytosis2008

    • Author(s)
      Hiroto Eguchi
    • Organizer
      The 12^<th>International Congress of Parki nson's disease and Movement disorders
    • Place of Presentation
      Chicago
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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