Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Research Abstract |
In this study, we show that PINK1 recruits Parkin from the cytoplasm to mitochondria with low membrane potential to initiate the autophagic degradation of damaged mitochondria. Furthermore, we identified FK506-binding protein 38 : FKBP38 as a PINK1 binding protein with mitochondrial uncoupler Carbonyl cyanide m-chliirophenilhydrazone : CCCP treatment and FKBP38 stabilized PINK1 at the protein level.
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