| Project/Area Number |
20790635
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Tohoku University |
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Principal Investigator |
IMAI Junta Tohoku University, 病院, 助教 (80431500)
|
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| Co-Investigator(Renkei-kenkyūsha) |
OKA Yoshitomo 東北大学, 大学院・医学系研究科, 教授 (70175256)
KATAGIRI Hideki 東北大学, 大学院・医学系研究科, 教授 (00344664)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 糖尿病 / 臓器関連関 / インスリン分泌 / 膵β細胞増殖 / 再生治療 / 自律神経 / 肝臓 / インスリン抵抗性 / 臓器間連関 |
|---|
| Research Abstract |
The mechanism underlying compensatory beta-cell responses against insulin resistance is not well understood. We have identified that a neuronal relay, originating in the liver, is involved in compensatory beta-cell responses during obesity development. In addition, we have shown that modulation of this neuronal relay may serve as a potential strategy for beta-cell regenerative medicine. These results were published in Science, one of the most famous scientific journals in the world, and were transmitted all over the world via various media.
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