Mechanism of pancreatic beta-cell regulation by signals from the liver
| Project/Area Number |
20790635
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
IMAI Junta Tohoku University, 病院, 助教 (80431500)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OKA Yoshitomo 東北大学, 大学院・医学系研究科, 教授 (70175256)
KATAGIRI Hideki 東北大学, 大学院・医学系研究科, 教授 (00344664)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 糖尿病 / 臓器関連関 / インスリン分泌 / 膵β細胞増殖 / 再生治療 / 自律神経 / 肝臓 / インスリン抵抗性 / 臓器間連関 |
|---|
| Research Abstract |
The mechanism underlying compensatory beta-cell responses against insulin resistance is not well understood. We have identified that a neuronal relay, originating in the liver, is involved in compensatory beta-cell responses during obesity development. In addition, we have shown that modulation of this neuronal relay may serve as a potential strategy for beta-cell regenerative medicine. These results were published in Science, one of the most famous scientific journals in the world, and were transmitted all over the world via various media.
|
Report
(3 results)
Research Products
(20 results)
-
-
-
[Journal Article] Peginterferon (PEG-IFN) plus ribavirin combination therapy, but neither interferon nor PGE-IFN alone, induced type 1 diabetes in a patient with chronic hepatitis C.2009
Author(s)
Ogihara T, Katagiri H, Yamada T, Kudo H, Imai J, Ishigaki Y, Hinokio Y, Yamagiwa Y, Ueno Y, Shimosegawa T, Oka Y
-
Journal Title
Intern Med 48
Pages: 1387-1390
NAID
Related Report
Peer Reviewed
-
-
[Journal Article] Peginterferon(PEG-IFN)plus ribavirin combination therapy, but neither interferon nor PGE-IFN alone, induced type 1 diabetes in a patient with chronic hepatitis C2009
Author(s)
Ogihara T, Katagiri H, Yamada T, Kudo H, Imai J, Ishigaki Y, Hinokio Y, Yamagiwa Y, Ueno Y, Shimosegawa T, Oka Y
-
Journal Title
Internal Medicine 48
Pages: 1387-1390
NAID
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis.2008
Author(s)
Ishigaki Y, Katagiri H, Gao J, Yamada T, Imai J, Uno K, Hasegawa Y, Kaneko K, Ogihara T, Ishihara H, Sato Y, Takikawa K, Nishimichi N, Matsuda H, Sawamura T, Oka Y
-
Journal Title
Circulation 118
Pages: 75-83
Related Report
Peer Reviewed
-
[Journal Article] Regulation of Pancreatic {beta} Cell Mass by Neuronal Signals from the Liver.2008
Author(s)
Imai J, Katagiri H, Yamada T, Ishigaki Y, Suzuki T, Kudo H, Uno K, Hasegawa Y, Gao J, Kaneko K, Ishihara H, Niijima A, Nakazato M, Asano T, Minokoshi Y, Oka Y
-
Journal Title
Science 322
Pages: 1250-1254
Related Report
Peer Reviewed
-
[Journal Article] Regulation of Pancreatic β Cell Mass by Neuronal Signals from the Liver2008
Author(s)
Imai J, Katagiri H, Yamada T, Ishigaki Y, Suzuki T, Kudo H, Uno K, Hasegawa Y, Gao J, K aneko K, Ishihara H, Niijima A, Nakazato M, Asano T, Minoko shi Y, Oka Y
-
Journal Title
Science 322
Pages: 1250-1254
Related Report
Peer Reviewed
-
[Journal Article] Impact of plasma oxidized lowdensity lipoprotein removal on atherosclerosis2008
Author(s)
Ishigaki Y, Katagiri H, Gao J, Yamada T, Imai J, Uno K, Hasegawa Y, Kaneko K, Ogihara T, Ishihara H, Sato Y, Takikawa K, Nishimichi N, Matsuda H, Sawamura T, Oka Y
-
Journal Title
Circulation 118
Pages: 75-83
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
