| Project/Area Number |
20790636
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Gunma University |
|---|
Principal Investigator |
MOGI Chihiro Gunma University, 生体調節研究所, 助教 (00375528)
|
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 骨芽細胞 / 破骨細胞 / Gタンパク質共役型受容体 / プロトン / pH / 骨 / シグナル伝達 |
|---|
| Research Abstract |
It is well known that extracellular pH plays important roles in bone remodeling, but the molecular mechanisms are yet unidentified. To reveal the roles of novel four proton-sensing receptors (OGR1, GPR4, TDAG8, G2A), we investigated the functions of OGR1 in human osteoblasts and murine osteoclasts. Moreover, we examined the bone mineral density in femurs obtained from receptor-knockout mice.
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