Research Project
Grant-in-Aid for Young Scientists (B)
Sirt1 links the energy availability status with cellular metabolism in peripheral organs. Insulin and leptin signaling regulate food intake in the arcuate nucleus of the hypothalamus. Sirt1 has been reported to improve insulin sensitivity in vitro, but the role of hypothalamic Sirt1 in regulating feeding has not been addressed. We found that hypothalamic Sirt1 protein level and stability is regulated by food intake. Forced expression of wild-type Sirt1 in the mediobasal hypothalamus suppressed hyperphagia and weight gain by suppressing the expression of the orexigenic neuropeptide AgRP.
All 2010 2009
All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (6 results)
Endocrinology (in press)