Liganded-thyroid hormone receptor-α enhances proliferation of pancreatic β-cells

• Project/Area Number: 20790644
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: University of Yamanashi
• Principal Investigator: FURUYA Fumihiko University of Yamanashi, 医学部附属病院, 診療助教 (90456450)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 膵臓 / 糖尿病 / 再生医療 / 核内ホルモン受容体 / 甲状腺ホルモン / 甲状腺 / 細胞周期

Research Abstract

Lineage tracing studies indicate that replication of existing beta-cells is important for beta-cell proliferation in adult animals. In rat pancreatic beta-cell lines (RIN5F), treatment with 100 nM of thyroid hormone (T3) enhances cell proliferation. This result suggests that T3 is required for beta-cell proliferation or replication.

Research Products

• [Journal Article] Nongenomic activation of phosphatidylinositol 3-kinase signaling by thyroid hormone receptors. (2009)
  • Author(s): Fumihiko Furuya
  • Journal Title: Epub 74(7) Pages: 628-634
  • Peer Reviewed
• [Journal Article] Nongenomic activation of phosphatidylinositol 3-kinase signaling by thyroidhormone receptors. (2009)
  • Author(s): 古屋文彦
  • Journal Title: Steroids 74(7) Pages: 628-634
  • Peer Reviewed
• [Journal Article] Activation of phosphatidylinositol 3-kinase signaling promotes aberrant pituitary growth in a mouse model of thyroid-stimulating hormone-secreting pituitary tumors. (2008)
  • Author(s): Fumihiko Furuya
  • Journal Title: Epub 149(7) Pages: 3339-3345
  • Peer Reviewed
• [Presentation] Liganded-thyroid hormone receptor induces proliferation of pancreatic β-cells (2010)
  • Author(s): 古屋文彦
  • Organizer: 国際内分泌学会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-20
• [Presentation] 甲状腺ホルモン受容体による膵β細胞増殖の誘導 (2009)
  • Author(s): 古屋文彦, 志村浩己, 山下さやか, 遠藤登代志, 小林哲郎
  • Organizer: 第52回日本甲状腺学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-04
• [Presentation] 副腎不全が原因と考えられる透析困難症がみられた糖尿病維持透析患者の1例 (2009)
  • Author(s): 古屋文彦, 池岸幸信, 小林哲郎
  • Organizer: 第563回日本内科学会関東地方会
  • Place of Presentation: 東京都
  • Year and Date: 2009-06-13
• [Presentation] 外来糖尿病患者および透析糖尿病患者におけるCAVI(Cardio Ankle Vascular Index)・ABI・SPP・およびASOの危険因子の検討 (2009)
  • Author(s): 古屋文彦, 本杉愛, 原口和貴, 高橋満彦, 今井亮, 小林みず江, 小林哲郎
  • Organizer: 第54回(社)日本透析医学会学術集会
  • Year and Date: 2009-06-05
• [Presentation] 膵β細胞における, 甲状腺ホルモン受容体αによる細胞周期進展と細胞増殖活性化の誘導 (2008)
  • Author(s): 古屋文彦, 志村浩己, 遠藤登代志, 小林哲郎
  • Organizer: 第51回日本甲状腺学会
  • Place of Presentation: 栃木県
  • Year and Date: 2008-11-22
• [Presentation] The Thyroid Hormone Receptor-α Mediates Cell Cycle Progression and Proliferation in Rat Pancreatic β-cells (2008)
  • Author(s): 古屋文彦
  • Organizer: 79 annual meeting of American thyroid association
  • Place of Presentation: Chicago
  • Year and Date: 2008-08-26
• [Book] インスリンポンプ療法マニュアル (2008)
  • Author(s): 小林哲郎
  • Total Pages: 177
  • Publisher: 南江堂