Role of Rho-associated kinase 2 in metabolic syndrome
Project/Area Number |
20790646
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Metabolomics
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Research Institution | Kyoto University |
Principal Investigator |
NOGUCHI Michio Kyoto University, 医学研究科, 特定研究員 (00432394)
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Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | ROCK2 / メタボリックシンドローム / 脂肪細胞分化 / ROCK / 糖代謝 |
Research Abstract |
We demonstrate that inhibition of ROCK2, not ROCK1, enhances adipogenesis accompanied by the upregulation of adipogenic transcription factors. Augmentation of insulin signaling may contribute to the enhancement of adipogenesis. Furtheremore, we focus on a cofactor as a novel mechanism associated with this pathway. ROCK2 heterozygous mice did not exhibit significant differences in metabolic parameters on standard chow and high fat diet compared with wild-type mice. Further studies will be needed.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells2009
Author(s)
D. Taura*, M. Noguchi*(* equally contributed), M. Sone, K. Hosoda, E. Mori, Y. Okada, K. Takahashi, K. Homma. N. Oyamada, M. Inuzuka, T. Sonoyama, K. Ebihara, N. Tamura, H. Itoh, H. Suemori, N. Nakatsuji, H. Okano, S. Yamanaka, K. Nakao
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Journal Title
FEBS Lett. 583(6)
Pages: 1029-1033
Related Report
Peer Reviewed
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[Journal Article] Glucocorticoid reamplification within cells intensifies NF{kappa}B andMAPK signaling and reinforces inflammation in activated preadipocytes2009
Author(s)
T. Ishii-Yonemoto, H. Masuzaki, S. Yasue, S. Okada, C. Kozuka, T. Tanaka, M. Noguchi, T. Tomita, J. Fujikura, Y. Yamamoto, K. Ebihara, K. Hosoda, K. Nakao
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Journal Title
Am J Physiol Endocrinol Metab 298
Pages: 930-940
Related Report
Peer Reviewed
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[Journal Article] Adipogenic differentiation of human induced pluripotent stem cells : comparison with that of human embryonic stem cells2009
Author(s)
D.Taura^*, M.Noguchi^*(^* equally contributed), M.Sone, K.Hosoda, E.Mori, Y.Okada, K.Takahashi, K.Homma.N.Oyamada, M.Inuzuka, T.Sonoyama, K.Ebihara, N.Tamura, H.Itoh, H.Suemori, N.Nakatsuji, H.Okano, S.Yamanaka, K.Nakao
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Journal Title
FEBS Lett. 583
Pages: 1029-1033
Related Report
Peer Reviewed
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[Journal Article] Glucocorticoid reamplification within cells intensifies NF{kappa}B and MAPK signaling and reinforces inflammation in activated preadipocytes2009
Author(s)
T.Ishii-Yonemoto, H.Masuzaki, S.Yasue, S.Okada, C.Kozuka, T.Tanaka, M.Nouchi, T.Tomita, J.Fujikura, Y.Yamamoto, K.Ebihara, K.Hosoda, K.Nakao
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Journal Title
Am J Physiol Endocrinol Metab. 298
Pages: 930-940
Related Report
Peer Reviewed
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[Journal Article] Adipose tissue-specific dysregulation of angiotensinogen by oxidative stress in obesity2009
Author(s)
S.Okada, C.Kozuka, H.Masuzaki, S.Yasue, T.Ishii-Yonemoto, T.Tanaka, Y.Yamamoto, M.Noguchi, T.Kusakabe, T.Tomita, J.Fujikura, K.Ebihara, K.Hosoda, H.Sakaue, H.Kobori, M.Ham, Y.S.Lee, J.B.Kim, Y.Saito, K.Nakao
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Genetic and pharmacological inhibition of Rho-associated kinase II enhances adipogenesis.2007
Author(s)
M. Noguchi, K. Hosoda, J. Fujikura, M. Fujimoto, H. Iwakura, T. Tomita, T. Ishii, N. Arai, M. Hirata, K. Ebihara, H. Masuzaki, H. Itoh, S. Narumiya, K. Nakao.
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Journal Title
J Biol Chem. 282
Pages: 29574-29583
Related Report
Peer Reviewed
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[Presentation] 脂肪細胞分化、糖代謝におけるROCK-IIの意義2008
Author(s)
野口倫生, 細田公則, 藤倉純二, 冨田努, 小鳥真司, 森栄作, 泰江慎太郎, 石井崇子, 岡田定規, 益崎裕章, 中尾一和
Organizer
第51回日本糖尿病学会年次学術集会
Place of Presentation
東京
Year and Date
2008-05-24
Related Report
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[Presentation] 脂肪細胞分化および糖代謝におけるROCK-IIの意義2008
Author(s)
野口倫生, 細田公則, 藤倉純二, 冨田努, 小鳥真司, 森栄作, 泰江慎太郎, 石井崇子, 岡田定規, 海老原健, 平田雅一, 益崎裕章, 中尾一和
Organizer
第81回日本内分泌学会学術総会
Place of Presentation
青森
Year and Date
2008-05-16
Related Report
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