| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
There are limits for pancreas transplantation in the treatment of type 1 diabetes owing to the shortage of organ donors. The research to generate beta cells from other differentiated pancreatic cells, such as acinar cells, in vivo is the promising approach. In the present study, cell lineage tracing showed that the acinar cell-specific expression of Pdx-1 reprogrammed the acinar cells and the newly generated beta cells were able to ameliorate STZ-induced diabetes.
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