Beta cell regeneration induced by the tetracycline-regulated expression of a pancreas-specific gene in mice.
| Project/Area Number |
20790647
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Osaka University |
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Principal Investigator |
MIYAZAKI Satsuki Osaka University, 医学系研究科, 特任研究員 (60452439)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 再生医療 / 膵β細胞 / 再生 / 転写因子 |
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| Research Abstract |
There are limits for pancreas transplantation in the treatment of type 1 diabetes owing to the shortage of organ donors. The research to generate beta cells from other differentiated pancreatic cells, such as acinar cells, in vivo is the promising approach. In the present study, cell lineage tracing showed that the acinar cell-specific expression of Pdx-1 reprogrammed the acinar cells and the newly generated beta cells were able to ameliorate STZ-induced diabetes.
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Report
(3 results)
Research Products
(35 results)
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[Journal Article] Gtsf1/Cue110, a gene encoding a protein with two copies of a CHHC Zn-finger motif, is involved in spermatogenesis and retrotransposon suppression in murine testes2009
Author(s)
Yoshimura T, Toyoda S, Kuramochi-Miyagawa S, Miyazaki T, Miyazaki S, Tashiro F, Yamato E, Nakano T, Miyazaki JI
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Journal Title
Developmental Biology 335
Pages: 216-27
Related Report
Peer Reviewed
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