• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of the prolyl isomerase Pin1 in diabetes

Research Project

Project/Area Number 20790648
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Metabolomics
Research InstitutionHiroshima University

Principal Investigator

NAKATSU Yusuke  Hiroshima University, 医歯薬学総合研究科, 助教 (20452584)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsPin1 / IRS-1 / インスリンシグナル / KOマウス / ob / obマウス / 糖尿病 / 糖新生系 / CRTC2 / インスリン
Research Abstract

We identified prolyl isomerase Pin1 as IRS-1 binding protein. Pin1 overexpression enhanced insulin signaling, while pin1 knockdown suppressed. In addition, overexpression of Pin1 in ob/ob mouse liver elevated IRS-1 mediating insulin signaling, while Pin1 KO mouse exhibited insulin resistance and glucose intolerance. Taking all of these results together, we conclude that Pin1 plays an important role in the enhancement of IRS-1 mediating insulin actions.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (14 results)

All 2010 2009 2008

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (7 results)

  • [Journal Article] Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy2010

    • Author(s)
      Cui X, Kushiyama A, Yoneda M, Nakatsu Y, (著者19人)
    • Journal Title

      Diabetes Res Clin Pract 87(1)

      Pages: 57-63

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy2010

    • Author(s)
      Cui X, Kushiyama A, Yoneda M, Nakatsu Y, Guo Y, Zhang J, Ono H, Kanna M, Sakoda H, Ono H, Kikuchi T, Fujishiro M, Shiomi M, Kamata H, Kurihara H, Kikuchi M, Kawazu S, Nishimura F, Asano T
    • Journal Title

      Diabetes Res Clin Pract. 87

      Pages: 57-63

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased SIRT1 expression and LKB1 phosphorylation occur with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase2010

    • Author(s)
      Yoneda M., Guo Y., Ono H., Nakatsu Y., Zhang J., Cui X., Iwashita M., Kumamoto S., Tsuchiya Y., Sakoda H., Fujishiro M, Kushiyama A., Koketsu Y., Kikuchi T., Kamata H., Nishimura F., Asano T.
    • Journal Title

      Obesity Res Clin Pract (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate2009

    • Author(s)
      Nakatsu Y, Kotake Y, Takishita T, Ohta S
    • Journal Title

      Toxicol Appl Pharmacol 240(2)

      Pages: 292-298

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate2009

    • Author(s)
      Nakatsu Y, Kotake Y, Takishita T, Ohta S.
    • Journal Title

      Toxicol Appl Pharmacol 240

      Pages: 292-298

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term forskolin stimulation induces AMPK activation and thereby enhances tight junction formation in human placental trophoblast BeWo cells2008

    • Author(s)
      Egawa M, Kamata H, Kushiyama A, Sakoda H, Fujishiro M, Horike N, Yoneda M, Nakatsu Y, (著者14人)
    • Journal Title

      Placenta 29(12)

      Pages: 1003-1008

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of AMP-activated protein kinase by tributyltin induces neuronal cell death2008

    • Author(s)
      Nakatsu Y, Kotake Y, Hino A, Ohta S
    • Journal Title

      Toxicol Appl Pharmacol 230(3)

      Pages: 358-363

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] プロリル異性化酵素Pin1はTORC2と結合しCRE活性を抑制することで、肝の糖新生系を制御する2009

    • Author(s)
      中津祐介、堀家なな緒、櫛山暁史、迫田秀之、大野晴也、神名真智、鎌田英明、栗原裕基、内田隆史、浅野知一郎
    • Organizer
      生化学会2009
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] プロリル異性化酵素Pin1はTORC2と結合しCRE活性を抑制することで、肝の糖新生系を制御する2009

    • Author(s)
      中津祐介
    • Organizer
      生化学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2009-10-23
    • Related Report
      2009 Final Research Report
  • [Presentation] Pin1 binds to IRS-1, and functions as a nutrient-sensing enhancer of insulin signaling2009

    • Author(s)
      Yusuke Nakatsu
    • Organizer
      アメリカ糖尿病学会
    • Place of Presentation
      アメリカ
    • Year and Date
      2009-06-25
    • Related Report
      2009 Final Research Report
  • [Presentation] Pin1 binds to IRS-1, and functions as a nutrient-sensing enhancer of insulin signaling2009

    • Author(s)
      Yusuke Nakatsu, Hideyuki Sakoda, Akifumi Kushiyama, Midori Fujishiro, Masayasu Yoneda, Haruya Ohno, Hideaki Kamata, Takafumi Uchida, Tomoichiro Asano
    • Organizer
      第69回アメリカ糖尿病学会
    • Place of Presentation
      アメリカルイジアナ州ニューホリンズ
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pin1はIRS-1と結合し、インスリンシグナルを促進する2009

    • Author(s)
      中津祐介
    • Organizer
      第52回日本糖尿病学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-21
    • Related Report
      2009 Final Research Report
  • [Presentation] プロリン異性化酵素Pin1はIRS-1のSer/Pro配列を認識し、結合する2008

    • Author(s)
      中津祐介
    • Organizer
      第81回日本生化学会・分子生物学会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-15
    • Related Report
      2009 Final Research Report
  • [Presentation] プロリン異性化酵素Pin1はIRS-1のSer/Pro配列を認識し、結合する2008

    • Author(s)
      中津祐介
    • Organizer
      生化学・分子生物学合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi