The expression of actin-binding protein filamin in the skeletal muscle of diabetic rodents

• Project/Area Number: 20790649
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: University of Toyama
• Principal Investigator: TESHIGAWARA Kiyoshi University of Toyama, 和漢医薬学総合研究所・民族薬物研究センター・薬効解析部, 研究員 (40403737)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: フィラミン / 糖脂質代謝 / 骨格筋 / 糖尿病

Research Abstract

The insulin resistance in skeletal muscle causes the onset and the development of type 2 diabetes mellitus. However, its molecular mechanism is unclear. In this study, we clarified the expression of filamin, which is one of actin-binding proteins, increased in the skeletal muscle of diabetic rodents compared with the normal rodents. This data indicate that filamin may have a physiological function for glucose metabolism in the skeletal muscle involved in the development of type 2 diabetes mellitus.

Research Products

• [Journal Article] Identification of cis-acting promoter sequences required for expression of the glycerol-3-phosphate acyltransferase 1 gene in mice (2009)
  • Author(s): Yoshida M, Harada N, Yamamoto H, Taketani Y, Nakagawa T, Yin Y, Hattori A, Zenitani T, Hara S, Yonemoto H, Nakamura A, Nakano M, Mawatari K, Teshigawara K, Arai H, Hosaka T, Takahashi A, Yoshimoto K, Nakaya Y.
  • Journal Title: Biochim Biophys Acta 1791(1) Pages: 39-52
  • NAID: 120006631417
  • Peer Reviewed
• [Journal Article] Reactive oxygen species induced by diamide inhibit insulin-induced ATP-sensitive potassium channel activation in cultured vascular smooth muscle cells (2008)
  • Author(s): Mawatari K, Yasui S, Morizumi R, Hamamoto A, Furukawa H, Koyama K, Hattori A, Yoshioka E, Yoshida M, Nakano M, Teshigawara K, Harada N, Hosaka T, Takahashi A, and Nakaya Y.
  • Journal Title: Asia Pac J Clin Nutr 17(S1) Pages: 162-6
  • Peer Reviewed
• [Journal Article] Alternative splicing produces a constitutively active form of human SREBP-1 (2008)
  • Author(s): Harada N, Yonemoto H, Yoshida M, Yamamoto H, Yin Y, Miyamoto A, Hattori A, Wu Q, Nakagawa T, Nakano M, Teshigawara K, Mawatari K, Hosaka T, Takahashi A, and Nakaya Y.
  • Journal Title: Biochem Biophys Res Commun 368(3) Pages: 820-6
  • Peer Reviewed
• [Presentation] Icariinによる記憶促進作用と作用機序の検討 (2009)
  • Author(s): 東田千尋、浦野卓矢、城屋敷枝里、長田愛子、勅使川原匡
  • Organizer: 日本薬理学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-17
• [Presentation] SNARE Binding Protein CSP1 Attenuates Insulin-Stimulated Glucose Uptake without Affecting GLUT4 Translocation in 3T3-L1 Adipocytes (2008)
  • Author(s): YOHKO HIRATA, TOSHIO HOSAKA, ERI TERADA, YUKA NISHIWAKI, BAYASGLAN JAMBALDORJ, QINKAI LI, KIYOSHI TESHIGAWARA, CHISATO KOSUGI, YUTAKA NAKAYA
  • Organizer: American diabetes association 68rd Scientific Sessions
  • Place of Presentation: San Francisco, California
  • Year and Date: 2008-06-06
• [Presentation] Serotonin Induces Insulin-Resistance in 3T3-L1 Adipocytes (2008)
  • Author(s): QINKAI LI, TOSHIO HOSAKA, BAYASGLAN JAMBALDORJ, RYO OTSUKA, YOHKO HIRATA, KIYOSHI TESHIGAWAWA, CHISATO KOSUGI, YUTAKA NAKAYA, MAKOTO FUNAKI
  • Organizer: American diabetes association 68rd Scientific Sessions
  • Place of Presentation: San Francisco, California
  • Year and Date: 2008-06-06
• [Presentation] 加圧空気治療(Hyperbaric air therapy : HBAT)の糖脂質代謝への影響の検討 (2008)
  • Author(s): 山口美輪、勅使川原匡、寺田依里、福永恵子、西脇由佳、Li Qinkai、平田容子、船木真理、中屋豊、保坂利男
  • Organizer: 日本糖尿病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-22
• [Presentation] SNARE結合タンパクCSP1は、細胞膜でのGLUT4小胞融合に作用して脂肪細胞でのインスリン依存性糖取り込みを抑制する (2008)
  • Author(s): 保坂利男、寺田依里、西脇由佳、冨岡有希子、岩島香織、Jambaldorj Bayasgalan、Qinkai Li、平田容子、勅使川原匡、船木真理、中屋豊
  • Organizer: 日本糖尿病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-22