The expression of actin-binding protein filamin in the skeletal muscle of diabetic rodents
Project/Area Number |
20790649
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Metabolomics
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Research Institution | University of Toyama |
Principal Investigator |
TESHIGAWARA Kiyoshi University of Toyama, 和漢医薬学総合研究所・民族薬物研究センター・薬効解析部, 研究員 (40403737)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | フィラミン / 糖脂質代謝 / 骨格筋 / 糖尿病 |
Research Abstract |
The insulin resistance in skeletal muscle causes the onset and the development of type 2 diabetes mellitus. However, its molecular mechanism is unclear. In this study, we clarified the expression of filamin, which is one of actin-binding proteins, increased in the skeletal muscle of diabetic rodents compared with the normal rodents. This data indicate that filamin may have a physiological function for glucose metabolism in the skeletal muscle involved in the development of type 2 diabetes mellitus.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Identification of cis-acting promoter sequences required for expression of the glycerol-3-phosphate acyltransferase 1 gene in mice2009
Author(s)
Yoshida M, Harada N, Yamamoto H, Taketani Y, Nakagawa T, Yin Y, Hattori A, Zenitani T, Hara S, Yonemoto H, Nakamura A, Nakano M, Mawatari K, Teshigawara K, Arai H, Hosaka T, Takahashi A, Yoshimoto K, Nakaya Y.
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Journal Title
Biochim Biophys Acta 1791(1)
Pages: 39-52
NAID
Related Report
Peer Reviewed
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[Journal Article] Reactive oxygen species induced by diamide inhibit insulin-induced ATP-sensitive potassium channel activation in cultured vascular smooth muscle cells2008
Author(s)
Mawatari K, Yasui S, Morizumi R, Hamamoto A, Furukawa H, Koyama K, Hattori A, Yoshioka E, Yoshida M, Nakano M, Teshigawara K, Harada N, Hosaka T, Takahashi A, and Nakaya Y.
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Journal Title
Asia Pac J Clin Nutr 17(S1)
Pages: 162-6
Related Report
Peer Reviewed
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[Journal Article] Alternative splicing produces a constitutively active form of human SREBP-12008
Author(s)
Harada N, Yonemoto H, Yoshida M, Yamamoto H, Yin Y, Miyamoto A, Hattori A, Wu Q, Nakagawa T, Nakano M, Teshigawara K, Mawatari K, Hosaka T, Takahashi A, and Nakaya Y.
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Journal Title
Biochem Biophys Res Commun 368(3)
Pages: 820-6
Related Report
Peer Reviewed
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