The molecular mechanism and physiological significance of thyroid hormone non-genomic action
Project/Area Number |
20790658
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Endocrinology
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Research Institution | Nagoya University |
Principal Investigator |
SOU Kasumi Nagoya University, 環境医学研究所, 助教 (70432218)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 甲状腺ホルモン / ノンゲノミック作用PI3K→Akt / ノンゲノミック作用 / シグナル伝達 / 甲状腺ホルモン(T3) / nongenomic作用 / シグナリング伝達 |
Research Abstract |
We have reported previously that thyroid hormone (T3) stimulates the PI3K/Akt pathway through thyroid hormone receptor (TR).It is a non-genomic action since the novel protein synthesis is not involved in. In the present study we demonstrated that T3 promotes the complex formation of TR/Src/p85, which induces the phosphorylation of Src and p85 sequentially and results in the activation of PI3K→Akt. This novel T3 action plays important role in neuronal cell survival.
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Report
(3 results)
Research Products
(12 results)