Anorectic pathway via Nesfatin-1 : cooperation of peripheral satiety factor-brainstem-hypothalamus
Project/Area Number |
20790663
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Endocrinology
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Research Institution | Jichi Medical University |
Principal Investigator |
MAEJIMA Yuko Jichi Medical University, 医学部, 助教 (40438669)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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Keywords | Nesfatin-1 / oxytocin / 室傍核 / melanocortin system / 生理学 / 摂食中枢 / 孤束核 / Nesfatln-1 |
Research Abstract |
We discovered that Nesfatin-1 induced anorexia via paraventricularoxytocin neurons, proopiomelanocortin neurons in NTS. In addition, we discovered thatNesfatin-1 is secretory peptides, and promote oxytocin release by aoutocrine or/and paracrine manner in PVN. The anorectic pathway described above is effective inleptin-resistant obese model.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] esfatin-1-regukated oxytocinergic signaling in the paraventricular Nucleus causes anorexia through a leptin-independent melanocortin pathway.2009
Author(s)
Yuko Maejima,Udval Sedbazar, ShigetomoSuyama, Daisuke Kohno,Tatsushi Onaka,Eisuke Takano,Natsu Yoshida,MasatoKoike,Yasuo Uchiyama, KenFujiwara,Takashi Yashiro, Tamas L.Horvath,Marcelo O. Dietrich, ShigeyasuTanaka, Katsuya Dezaki,Shinsuke Oh-I,Koushi Hashimoto, HiroyukiShimizu,Masanori Nakata, Masatomo Mori, Toshihiko Yada.
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Journal Title
Cell Metabolism 10
Pages: 355-365
Related Report
Peer Reviewed
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