Oxidative stress induced change of Ubiquitin modification in Mineralocorticoid receptor and cardiovascular disorder

Research Project

Project/Area Number	20790664
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Endocrinology
Research Institution	The University of Tokyo
Principal Investigator	YOKOTA Kenichi The University of Tokyo, 分子細胞生物学研究所, 特任研究員 (50424156)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	MR / アルドステロン / ユビキチン / 転写 / エピゲノム
Research Abstract	Mineralocorticoid receptor(MR) is ubiquitinated and then led to proteasome mediated degradation by its ligand, Aldosterone.It is possible that oxidative stress may modify MR ubiquitination and thus change MR mediated transcription.The E3 ligase that regulates MR degradation is possibly UBR2 and it may modify MR degradation under oxidative stress.

Report

(3 results)