Establishment of experimental model for leukemia to develop novel molecular therapy
| Project/Area Number |
20790669
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
GOYAMA Susumu The University of Tokyo, 医学部・附属病院, 助教 (80431849)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 白血病 / モデルマウス / 新規治療法 / Evi-1 / 難治性白血病 / マウス白血病モデル / Pten / Akt / mTorシグナル伝達経路 / 分子標的療法 / 造血幹細胞 / 白血病幹細胞 / MLL / Pbxl / ヒストンメチル化酵素 |
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| Research Abstract |
Aberrant expression of Evi-1 has been shown as a poor-prognosis marker for acute myeloid leukemia (AML). In this study, we developed a colony replating assay to replicate Evi-1-related leukemia. Using this assay, we found several molecular mechanisms underlying Evi-1-mediated leukemogenesis as follows : (1) Evi-1 is upregulated by MLL oncoproteins. (2) Evi-1 activates Pbx1 and Akt/mTor pathway. (3) Evi-1 interacts with histone methyltransferases and polycomb complexes. Furthermore, we showed these factors are important for leukemogenic activities of Evi-1. These results provide a foundation to develop novel therapeutic strategies for AML.
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Report
(3 results)
Research Products
(38 results)
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[Presentation] EVI1 Represses PTEN Transcription and Activates AKT/mTOR Through Interaction with Polycomb Repressor complexes2009
Author(s)
吉見昭秀, 渡辺-大河内直子, 合山進, 南谷泰仁, 仁田英里子, 荒井俊也, 佐藤智彦, 島辺宗健, 中川正宏, 今井陽一, 北村俊雄, 黒川峰夫
Organizer
第71回日本血液学会総会
Place of Presentation
京都
Year and Date
2009-10-24
Related Report
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[Presentation] EVI1はポリコーム群を介してPTENの転写抑制しAKT/mTORシグナルを活性化する2009
Author(s)
吉見昭秀, 渡辺-大河内直子, 合山進, 南谷泰仁, 仁田英里子, 荒井俊也, 佐藤智彦, 島辺宗健, 中川正宏, 今井陽一, 北村俊雄, 黒川峰夫
Organizer
第68回日本癌学会学術総会
Place of Presentation
横浜
Year and Date
2009-10-03
Related Report
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[Presentation] Evi-1 Interacts with Histone Methyltransferases for Transcription Repression and Bone. Marrow Transformation2008
Author(s)
Goyama S, Nitta E, Shimabe M, Yoshino T, Kako S, Ichikawa M, Imai Y, Takahashi T, Hangaishi A, Kurokawa M
Organizer
50th American Society of Hematology Annnual Meeting
Place of Presentation
San Francisco, U.S.A.
Year and Date
2008-12-08
Related Report
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[Presentation] Evi-1 Interacts with Histone Methyltransferases for Transcription Repression and Bone Marrow Transformation.2008
Author(s)
合山進, 仁田英理子, 島辺宗健, 吉野哲也, 賀古真一, 市川幹, 今井陽一, 高橋強志, 半下石明, 黒川峰夫
Organizer
50th American Society of Hematology Annnual Meeting.
Place of Presentation
San Francisco, U.S.A.
Related Report
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