Functional analysis of AML1-target genes in hematological malignancy.
Project/Area Number |
20790670
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Hematology
|
Research Institution | The University of Tokyo |
Principal Investigator |
NAKAGAWA Masahiro The University of Tokyo, 医学部・附属病院, 助教 (10431850)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 血液内科学 / シグナル伝達 / 癌 / 白血病 / AML1 / NF-kB |
Research Abstract |
AML1-related leukemia exhibits distinctly activated NF-kB signaling. Inhibition of the NF-kB pathway in the leukemic cells with mutated AML1 efficiently blocks their growth.
|
Report
(3 results)
Research Products
(13 results)