Functional analysis of AML1-target genes in hematological malignancy.

• Project/Area Number: 20790670
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: The University of Tokyo
• Principal Investigator: NAKAGAWA Masahiro The University of Tokyo, 医学部・附属病院, 助教 (10431850)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 血液内科学 / シグナル伝達 / 癌 / 白血病 / AML1 / NF-kB

Research Abstract

AML1-related leukemia exhibits distinctly activated NF-kB signaling. Inhibition of the NF-kB pathway in the leukemic cells with mutated AML1 efficiently blocks their growth.

Research Products

• [Journal Article] AML1 enhances the epression of leukotriene B4 type-1 receptor in leukocytes (2010)
  • Author(s): Hashidate T, Nakamura M, Nakagawa M, Ichikawa M, Kurokawa M, Shimizu T.
  • Journal Title: FASEB Journal (in press)
  • Peer Reviewed
• [Presentation] AML1/Runx1 is a cytoplasmic attenuator of NF-kB signaling: implication in pathogenesis and targeted therapy of AML1-related leukemia. (2010)
  • Author(s): Nakagawa M, Shimabe M, Nishimoto N, Watanabe-Okochi N, Ichikawa M, Nannya Y, Imai Y, Kurokawa M.
  • Organizer: Keystone symposia "New Paradigms in Cancer Therapeutics"
  • Place of Presentation: Victoria, Canada
  • Year and Date: 2010-03-25
• [Presentation] AML1/Runx1 is a cytoplasmic attenuator of NF-kB signaling : implication in pathogenesis and targeted therapy of AML1-related leukemia (2010)
  • Author(s): Nakagawa M, Shimabe M, Nishimoto N, Watanabe-Okochi N, Ichikawa M, Nannya Y, Imai Y, Kurokawa M.
  • Organizer: Keystone symposia "New Paradigms in Cancer Therapeutics"
  • Place of Presentation: Victoria, Canada
  • Year and Date: 2010-03-25
• [Presentation] AML1/Runx1 is a cytoplasmic attenuator of NF-kB signaling: implication in pathogenesis and targeted therapy of AML1-related leukemia. (2009)
  • Author(s): Nakagawa M, Shimabe M, Nishimoto N, Watanabe-Okochi N, Ichikawa M, Nannya Y, Imai Y, Kurokawa M
  • Organizer: The American Society of Hematology 51th Annual Meeting
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2009-12-05
• [Presentation] AML1/Runx1 is a cytoplasmic attenuator of NF-kB signaling : implication in pathogenesis and targeted therapy of AML1-related leukemia (2009)
  • Author(s): Nakagawa M, Shimabe M, Nishimoto N, Watanabe-Okochi N, Ichikawa M, Nannya Y, Imai Y, Kurokawa M.
  • Organizer: The American Society of Hematology 51^<th> Annual Meeting
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2009-12-05
• [Presentation] AML1/Runx1によるNF-κBシグナルの制御 (2009)
  • Author(s): 中川正宏, 今井陽一, 西本菜穂子, 市川幹, 黒川峰夫
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-24
• [Presentation] AML1/Runx1によるNF-κBシグナルの制御 (2009)
  • Author(s): 中川正宏, 今井陽一, 西本菜穂子, 市川幹, 黒川峰夫
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] Critical regulation of NF-kB signaling by AML1/Runx1 in normal and malignant hematopoietic cells. (2009)
  • Author(s): Nakagawa M, Imai Y, Nishimoto N, Ichikawa M, Kurokawa M
  • Organizer: he 2009 International RUNX Meeting
  • Place of Presentation: Oxford, UK
  • Year and Date: 2009-08-19
• [Presentation] Critical regulation of NF-kB signaling by AML1/Runxl in normal and malignant hematopoietic cells (2009)
  • Author(s): Nakagawa M, Imai Y, Nishimoto N, Ichikawa M, Kurokawa M.
  • Organizer: The 2009 International RUNX Meeting
  • Place of Presentation: Oxford, UK
  • Year and Date: 2009-08-19
• [Presentation] 白血病関連転写因子AML1/Runx1によるNF-κBシグナルの制御. (2009)
  • Author(s): 中川正宏, 今井陽一, 黒川峰夫
  • Organizer: 第13回日本がん分子標的治療学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 2009-06-25
• [Presentation] 白血病関連転写因子AML1/Runx1によるNF-κBシグナルの制御 (2009)
  • Author(s): 中川正宏, 今井陽一, 黒川峰夫
  • Organizer: 第13回日本がん分子標的治療学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 2009-06-25
• [Presentation] AML1/Runx1 regulates NF?-kB signaling in murine hematopoietic stem and progenitor cells (2008)
  • Author(s): 中川正宏
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] 造血幹細胞におけるAML1/Runx1の転写標的ネットワークの解明 (2008)
  • Author(s): 中川正宏
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-11