In vivo characterization of B cells with lymphoma-specific translocat in mice and their potential roles in lymphoma development.

• Project/Area Number: 20790673
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: Kyoto University
• Principal Investigator: NISHIKORI Momoko Kyoto University, 医学研究科, 助教 (60378635)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 染色体転座 / BCL2 / 悪性リンパ腫

Research Abstract

To clarify how the BCL2/IGH translocation contributes to the development of lymphoma of germinal center B-cell origin, we used chimeric mouse models to examine the biological features of BCL2-overexpressing B cells. These cells showed a cell-autonomous differentiation preference for follicular B cells, and they have reduced responsiveness to terminal differentiation stimulation. We hypothesize that B cells that have undergone BCL2/IGH translocation might possibly be forced to localize in follicles, and accumulate genetic abnormalities by being subjected to recurrent stimulation.

Research Products

• [Journal Article] Distinctive cell properties of B cells carrying the BCL2 translocation and their potential roles in the development of lymphoma of germinal center type. (2009)
  • Author(s): Sakai T, Nishikori M, Tashima M, et al.
  • Journal Title: Cancer Sci 100 Pages: 2361-2367
  • NAID: 10027198345
  • Peer Reviewed
• [Journal Article] B7-H1 expression is regulated by MEK/ERK signaling pathway in anaplastic large cell lymphoma and Hodgkin lymphoma. (2009)
  • Author(s): Yamamoto R, Nishikori M, Tashima M, et al
  • Journal Title: Cancer Sci 100 Pages: 2093-3100
  • NAID: 10027196899
  • Peer Reviewed
• [Journal Article] Distinctive cell properties of B cells carrying the BCL2 translocation and their potential roles in the development of lymphoma of germinal center type. (2009)
  • Author(s): Tomomi Sakai, Momoko Nishikori, 他7名
  • Journal Title: Cancer Science 100 Pages: 2361-2367
  • NAID: 10027198345
  • Peer Reviewed
• [Journal Article] B7-H1 expression is regulated by MEK/ERK signaling pathway in anaplastic large cell lymphoma and Hodgkin lyphoma. (2009)
  • Author(s): Ryo Yamamoto, Momoko Nishikori, 他6名
  • Journal Title: Cancer Science 100 Pages: 2093-2100
  • Peer Reviewed
• [Journal Article] PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma. (2008)
  • Author(s): Yamamoto R, Nishikori M Kitawaki T, et al.
  • Journal Title: Blood 111 Pages: 3220-3224
  • NAID: 40019063953
  • Peer Reviewed
• [Presentation] 内山卓未分化大細胞型リンパ腫とホジキンリンパ腫におけるB7-H1の発現制御機構 (2009)
  • Author(s): 山本玲、錦織桃子、田嶌政治、坂井智美、一戸辰夫、高折晃史
  • Organizer: 第71回日本血液学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-23
• [Presentation] 低悪性度リンパ腫の病態と治療-濾胞性リンパ腫と辺縁帯リンパ腫-。教育講演S-2. (2009)
  • Author(s): 錦織桃子
  • Organizer: 第71回日本血液学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-23
• [Presentation] 低悪性度リンパ腫の病態と治療-濾胞性リンパ腫と辺縁帯リンパ腫- (2009)
  • Author(s): 錦織桃子
  • Organizer: 第71回日本血液学会学術総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-10-23
• [Presentation] 未分化大細胞型リンパ腫とホジキンリンパ腫におけるB7-H1の発現制御機構 (2009)
  • Author(s): 山本玲、錦織桃子, 他5名
  • Organizer: 第71回日本血液学会学術総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-10-23
• [Presentation] 慢性甲状腺炎を背景に発症した甲状腺T細胞リンパ腫の2例 (2009)
  • Author(s): 田罵政治、錦織桃子, 他3名
  • Organizer: 第49回日本リンパ網内系学会総会
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2009-07-11
• [Presentation] B Cells with BCL2/IGH Translocation Compose a Distinctive Cell Population That May Serve as a Reservoir of Lymphoma of Germinal Center B-Cell Type. (2008)
  • Author(s): Tomomi Sakai, Momoko Nishikori, Masaharu Tashima, Ryo Yamamoto, Toshio Kitawaki, Akifumi Takaori-Kondo, Shinobu Tsuzuki, Takashi Uchiyama
  • Organizer: 50th American Society of Hematology Annual Meeting and Exposition
  • Place of Presentation: 米国サンフランシスコ
  • Year and Date: 2008-12-08
• [Presentation] Bcells with BCL2/IGH translocation compose a distinctive cell population that may serve as a reservoir of germinal center B-cell type (2008)
  • Author(s): Tomomi Sakai, Momoko Nishikori, 他6名
  • Organizer: 50th Annual Meetilng of the American Society of Hematology
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2008-12-07
• [Presentation] Differentiation preference determined by BCL2 translocation potentially leads to B-cell lymphoma of germinal center type (2008)
  • Author(s): Masaharu Tashima, Momoko Nishikori, 他6名
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] BCL2転座陽性B細胞の生理学的特徴と分化指向性の解析 (2008)
  • Author(s): 坂井智美, 錦織桃子, 他5名
  • Organizer: 第70回日本血液学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-11
• [Presentation] BCL2転座陽性B細胞の生理学的特徴と分化指向性の解析. (2008)
  • Author(s): 坂井智美, 錦織桃子, 田嶌政治, 北脇年雄, 山本玲, 高折晃史, 内山卓
  • Organizer: 第70回日本血液学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-10
• [Presentation] T細胞性リンパ腫症例における末梢血T細胞のPD-1発現の意義 (2008)
  • Author(s): 山本玲, 田嶌政治, 錦織桃子, 他7名
  • Organizer: 第70図日本血液学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-10
• [Presentation] Characterizing biological features of B cells carrying BCL2/IGH translocation. (2008)
  • Author(s): Tomomi Sakai, Momoko Nishikori, Toshio Kitawaki, Masaharu Tashima, Ryo Yamamoto, Takashi Uchiyama
  • Organizer: 10th International Conference on Malignant Lymphoma
  • Place of Presentation: スイスルガノ
  • Year and Date: 2008-06-06
• [Presentation] Characterizing biological features of B cells carrying BCL2/IGH translocation (2008)
  • Author(s): Tomomi Sakai, Momoko Nishikori, 他4名
  • Organizer: 10th International Conference on Malignant Lymphoma
  • Place of Presentation: ルガノ(スイス)
  • Year and Date: 2008-06-06
• [Remarks]
  • URL: http://www.kuhp.kyoto-u.ac.jp/%7Ehemonc/hematolindex.html