| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
We recently identified a novel gene with a similar CCCH-type zinc finger domain as a possible tumor suppressor gene that is involved in a cryptic breakpoint translocation found in human transformed follicular lymphoma. To clarify clinical significance for the gene, we analyzed the gene defect of 84 lymphoma patients. Eleven patients (15.3%) lose at least one allele. TFL protein inhibited cell growth and provoked apoptosis. As for its subcellular localization, it localized in the cytoplasmic granules called P-bodies. The inhibitory activity of TFL for lymphocyte proliferation highlights the potential utility of TFL as therapeutic targets for leukemia and/or lymphoma.
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