Analysis of induction mechanisms for tumor antigen-specific regulatory T cells in lymphoma
| Project/Area Number |
20790681
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Keio University |
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Principal Investigator |
MATSUSHITA Maiko Keio University, 医学部, 助教 (10327520)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 悪性リンパ腫 / 制御性T細胞 / がん抗原 / 腫瘍抗原 |
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| Research Abstract |
To analyze the development mechanisms of regulatory T (Treg) cells in B cell lymphoma patients, we established a model system using 5C.C7 TCR-Tg/RAG^<-/-> mice and B cell lymphoma cells expressing antigen peptides with various TCR affinities and expression levels. We showed that intrathymically-injected agonistic antigen peptides could induce Treg cells in peripheral lymphoid tissues with high efficiency.
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Report
(3 results)
Research Products
(2 results)
