Analysis of induction mechanisms for tumor antigen-specific regulatory T cells in lymphoma

• Project/Area Number: 20790681
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: Keio University
• Principal Investigator: MATSUSHITA Maiko Keio University, 医学部, 助教 (10327520)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 悪性リンパ腫 / 制御性T細胞 / がん抗原 / 腫瘍抗原

Research Abstract

To analyze the development mechanisms of regulatory T (Treg) cells in B cell lymphoma patients, we established a model system using 5C.C7 TCR-Tg/RAG^<-/-> mice and B cell lymphoma cells expressing antigen peptides with various TCR affinities and expression levels. We showed that intrathymically-injected agonistic antigen peptides could induce Treg cells in peripheral lymphoid tissues with high efficiency.

Research Products

• [Journal Article] Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication (2009)
  • Author(s): Zhong XS, Matsushita M, Plotkin J, Riviere I, Sadelain M.
  • Journal Title: Mol Ther. 18 Pages: 413-420
• [Journal Article] Chimeric antigen receptors combining, 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication. (2009)
  • Author(s): Zhong XS, Matsushita M, Plotkin J, Riviere I, Sadelain M.
  • Journal Title: Mol Ther. 18 Pages: 413-420
  • Peer Reviewed