Ligand screening and functional analysis of Tie1
| Project/Area Number |
20790685
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
MOMOSE Haruka National Institute of Infectious Diseases, 血液・安全性研究部, 主任研究官 (70415488)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 血液免疫学 / 造血幹細胞 / 血液学 / 幹細胞 |
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| Research Abstract |
Hematopoietic stem cells (HSCs) are clonogenic cells which possess self-renewal capacity and pluripotency for the maintenance and the repair of whole blood system. The regulation of HSCs is very important for blood homeostasis, however, the precise molecular mechanisms regulating HSCs remain elusive. In this work, I focused on Tie1, a receptor tyrosine kinase which is expressed in HSCs. I had searched ligands of this orphan receptor to understand the function of Tie1. Several candidates were identified.
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Report
(3 results)
Research Products
(11 results)
