| Project/Area Number |
20790694
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
YAMAMOTO Motohisa Sapporo Medical University, 医学部, 助教 (80404599)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | IgG4関連疾患 / ミクリッツ病 / プロテオミクス / 免疫沈降 / 自己抗原 |
|---|
| Research Abstract |
Mikulicz's disease is a representative disorder of systemic IgG4-related disease. Interestingly, hypocomplementemia is observed in a quarter of the patients with Mikulicz's disease, and circulating immune complexes are detected in a half of them. We extracted immune complexes from the serum of Mikulicz's disease patients by immuno-precipitation. The antigens, which consisted of the immune complexes, were gotten by acid dissociation. Proteomic analysis revealed a 13.1 kD protein. We expect that the detection of this protein in the serum leads to more accurate diagnosis of systemic IgG4-related disease.
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