| Project/Area Number |
20790700
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
膠原病・アレルギー・感染症内科学
|
|---|
| Research Institution | National Research Institute for Child Health and Development |
|---|
Principal Investigator |
KAJIWARA Naoki National Research Institute for Child Health and Development, 大学院・医学研究科, 博士研究員 (70453917)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OKAYAMA Yoshimichi 日本大学, 大学院・医学研究科, 准教授 (80292605)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | マスト細胞 / 血小板活性化因子受容体 / ヒスタミン / 脱顆粒 / アレルギー / アレルギー・ぜんそく / 血小板活性化因子 / PAF |
|---|
| Research Abstract |
In this study, we demonstrated for the first time that PAF induces histamine release from human lung mast cells but not human skin mast cells. PAF receptor on human peripheral blood-derived cultured mast cells coupled to pertussis toxin-sensitive Gi protein and activated PLC・2 and PLC・1 in response to PAF. These observations have important implications for our understanding of the mechanisms of acute allergic diseases, in particular asthma.
|
