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The analysis of FTY720 effect on Treg and arthritis in SKG mice

Research Project

Project/Area Number 20790701
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionHyogo College of Medicine

Principal Investigator

TSUNEMI Sachi  Hyogo College of Medicine, 医学部, ポストドクター (80425123)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords関節リウマチ / スフィンゴシン1リン酸(S1P) / FTY720 / SKGマウス / 制御性T細胞(Treg)
Research Abstract

FTY720(a high-affinity agonist for sphingosine 1-phosphate receptors) administration suppressed the progression of laminarin-induced arthritis in rheumatoid arthritis (RA) model of SKG mice. FTY720 can inhibit arthritis in SKG mice via sequestration of autoimmune CD4^+ T cells in the thymus, enhancement of Th2 immune responses, and inhibition of PGE_2 production by synovial cells.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (27 results)

All 2010 2009 2008 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (23 results) Remarks (1 results)

  • [Journal Article] Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model.2010

    • Author(s)
      Tsunemi S, Iwasaki T, Kitano S, Imado T, Miyazawa K, Sano H.
    • Journal Title

      Clinical Immunology

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model2010

    • Author(s)
      Tsunemi sachi
    • Journal Title

      Clinical Immunology (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自己免疫疾患におけるスフィンゴシン1-リン酸(S1P)/S1Pレセプターシグナルの役割-関節リウマチとシェーグレン症候群を中心に-2008

    • Author(s)
      北野将康, 関口昌弘, 常見幸, 橋本尚明, 岩崎剛, 佐野統
    • Journal Title

      Minophagen Medical Review 53

      Pages: 135-145

    • Related Report
      2009 Final Research Report
  • [Presentation] Multiple effects of FTY on the immue system, inflammation, and bone remodeling in rheumatoid arthritis2009

    • Author(s)
      Iwasaki tsuyoshi, Tsunemi sachi
    • Organizer
      The 73th Annual Scientific Meeting of the American College of Rheumatology(ACR/ARHP2009)
    • Place of Presentation
      America, Philadelphia
    • Year and Date
      2009-10-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of FTY720 on bone remodeling in rheumatoid arthritis2009

    • Author(s)
      Kanda C, Iwasaki T, Tsunemi S, Kitano S, Takeshita H, Sano H.
    • Organizer
      The 73th Annual Scientific Meeting of the American College of Rheumatology
    • Place of Presentation
      Philadelphia, U.S.A.
    • Year and Date
      2009-10-16
    • Related Report
      2009 Final Research Report
  • [Presentation] スフィンゴシン1燐酸(S1P)/S1P受容体シグナルの関節リウマチ病態における役割2009

    • Author(s)
      北野将康, 常見幸, 竹下治範, 神田ちえり, 関口昌弘, 岩崎剛, 佐野統
    • Organizer
      第19回日本リウマチ学会近畿支部学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-09-05
    • Related Report
      2009 Final Research Report
  • [Presentation] The role of sphingosine 1-phosphate/S1P1 signaling in the osteoclastogenesis of rheumatoid arthritis2009

    • Author(s)
      Kitano M, Takeshita H, Tsunemi S, Kanda C, Sekiguchi M, Azuma N, Iwasaki T, Sano H.
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] 関節リウマチの骨再生におけるFTY720の効果2009

    • Author(s)
      Kanda C, Iwasaki T, Tsunemi S, Kitano S, Takeshita H, Sano, H.
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] FTY720の関節炎抑制効果機序に関する検討2009

    • Author(s)
      常見幸, 岩崎剛, 北野幸恵, 神田ちえり, 関口昌弘, 北野将康, 佐野統
    • Organizer
      第37回日本臨床免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Multiple effects of FTY on the immune system, inflammation, and bone remodeling in rheumatoid arthritis2009

    • Author(s)
      Iwasaki T, Tsunemi S, Kitano S, Kanda C, Sano H.
    • Organizer
      The 73th Annual Scientific Meeting of the American College of Rheumatology
    • Place of Presentation
      Philadelphia, U.S.A.
    • Related Report
      2009 Final Research Report
  • [Presentation] The role of sphingosine 1-phosphate /S1P1 signaling in the osteoclastogenesis of rheumatoid arthritis2009

    • Author(s)
      Kitano M, Takeshita H, Tsunemi S, Kanda C, Sekiguchi M, Azuma N, Iwasaki T.
    • Organizer
      The 73th Annual Scientific Meeting of the American College of Rheumatology
    • Place of Presentation
      Philadelphia, U.S.A.
    • Related Report
      2009 Final Research Report
  • [Presentation] シェーグレン症候群(SS)におけるTh17細胞と制御性T細胞の役割-S1P1/FTY720シグナルの関与について2009

    • Author(s)
      関口昌弘, 岩崎剛, 神田ちえり, 西岡亜紀, 常見幸, 東直人, 北野将康, 黒岩孝則, 橋本尚明, 松井聖, 佐野統
    • Organizer
      第53回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 関節リウマチ発症におけるスフィンゴシン1リン酸(S1P)/S1P受容体シグナルの役割2009

    • Author(s)
      佐野統, 北野将康, 常見幸, 関口昌弘, 神田ちえり, 西岡亜紀, 東直人, 黒岩孝則, 橋本尚明, 松井聖, 岩崎剛
    • Organizer
      第53回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 関節リウマチ滑膜細胞でのRANKL発現におけるスフィンゴシン1リン酸(S1P)/S1P受容体シグナルの役割2009

    • Author(s)
      北野将康, 竹下治範, 神田ちえり, 常見幸, 西岡亜紀, 関口昌弘, 東直人, 黒岩孝則, 橋本尚明, 松井聖, 岩崎剛, 佐野統
    • Organizer
      第53回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 関節リウマチモデルマウスにおけるFTY720による関節炎抑制効果2008

    • Author(s)
      常見幸
    • Organizer
      第2回YRAR(Young Researchers in Advanced Rhematology)
    • Place of Presentation
      大阪
    • Year and Date
      2008-01-05
    • Related Report
      2009 Final Research Report
  • [Presentation] 関節リウマチモデルマウスに対するFTY720による関節炎抑制効果の検討/Suppression of arthritis in a murine arthritis model by FTY7202008

    • Author(s)
      常見幸, 岩崎剛, 北野幸恵, 関口昌弘, 今戸健人, 北野将康, 佐野統
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] 関節リウマチ滑膜細胞でのRANKL発現におけるSphingosine 1-phosphate/S1P1シグナルの役割2008

    • Author(s)
      北野将康, 竹下治範, 北野幸恵, 関口昌弘, 常見幸, 黒岩孝則, 橋本尚明, 松井聖, 岩崎剛, 佐野統
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] FTY720によるSKGマウス関節炎抑制効果2008

    • Author(s)
      常見幸、関口昌弘、北野将康、今戸健人、北野幸恵、岩崎剛、佐野統
    • Organizer
      第3回スフィンゴテラピィ研究会
    • Place of Presentation
      鳥取
    • Related Report
      2009 Final Research Report
  • [Presentation] 関節リウマチモデルマウスにおけるFTY720による関節炎抑制効果2008

    • Author(s)
      常見幸, 関口昌弘, 北野将康, 佐野統
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] シェーグレン症候群の病態形成におけるS1PとFTY720の関与2008

    • Author(s)
      関口昌弘, 常見幸, 北野将康, 佐野統
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Treatment of a murine arthritis model2008

    • Author(s)
      Tsunemi S, Iwasaki T, Kitano M, Sekiguchi M, Kitano S, Imado T, Sano H
    • Organizer
      SKG mouse, by FTY720 a new immunosuppressant. The annual European Congress of Rheumatology
    • Place of Presentation
      Paris, France
    • Related Report
      2009 Final Research Report
  • [Presentation] The role of sphingosine 1-Phosphate/S1P1 signaling in the osteoclastogenesis via RANKL expression of rheumatoid synoviocytes2008

    • Author(s)
      Kitano M, Takeshita H, Tsunemi S, Kitano S, Sekiguchi M, Nishioka A, Azuma N, Hashimoto N, Iwasaki T, Hla T, Sano H.
    • Organizer
      Annual European Congress of Rheumatology(EULAR2008)
    • Place of Presentation
      Paris, France
    • Related Report
      2009 Final Research Report
  • [Presentation] 炎症性サイトカインはリウマチ滑膜細胞でのスフィンゴシン1燐酸/スフィンゴシン1燐酸レセプター1シグナルを増強する2008

    • Author(s)
      北野将康, 関口昌弘, 常見幸, 神田ちえり, 西岡亜紀, 東直人, 黒岩孝則, 橋本尚明, 松井聖, 岩崎剛, 佐野統
    • Organizer
      第52回日本リウマチ学会総会・学術集会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] FTY720投与による関節リウマチモデルマウスにおける関節炎抑制効果2008

    • Author(s)
      関口昌弘, 岩崎剛, 常見幸, 佐野統
    • Organizer
      第52回日本リウマチ学会総会・学術集会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] Treatment of a murine arthritis model, SKG mouse, by FTY720 a new immunosuppressant2008

    • Author(s)
      S. Tsunemi
    • Organizer
      The European League Against Rheumatism (EULAR)2008
    • Place of Presentation
      Paris, France
    • Related Report
      2008 Annual Research Report
  • [Presentation] 関節リウマチモデルマウスに対するFTY720による関節炎抑制効果の検討2008

    • Author(s)
      常見幸
    • Organizer
      第38回日本免疫学会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.hyo-med.ac.jp/department/rhmt/index.html

    • Related Report
      2009 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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