Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Research Abstract |
FTY720(a high-affinity agonist for sphingosine 1-phosphate receptors) administration suppressed the progression of laminarin-induced arthritis in rheumatoid arthritis (RA) model of SKG mice. FTY720 can inhibit arthritis in SKG mice via sequestration of autoimmune CD4^+ T cells in the thymus, enhancement of Th2 immune responses, and inhibition of PGE_2 production by synovial cells.
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