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Analysis of IL-33-induced asthma model

Research Project

Project/Area Number 20790706
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionNational Research Institute for Child Health and Development

Principal Investigator

OBOKI Keisuke  National Research Institute for Child Health and Development, 免疫アレルギー研究部, 共同研究員 (80415108)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsIL-33 / マスト細胞 / 喘息モデル / CD4+T細胞
Research Abstract

Asthma is a syndrome with a heterogeneous phenotype. However, the pathogenic mechanisms of this heterogeneity are still largely unknown. To investigate the asthma-related roles of IL-33, which was reported in 2005 as an allergenic cytokine, I have established and studied a new mouse model of asthma. Using this model, I have been observed a part of the severe asthma manifestation and acquired some novel mechanisms in IL-33-related pathogenic inflammation.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (29 results)

All 2010 2009 2008 2007 Other

All Journal Article (24 results) (of which Peer Reviewed: 4 results) Presentation (2 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Amphiregulin is not essential for ovalbumin-induced acute airway inflammation in mice.2010

    • Author(s)
      Kajiwara N, Oboki K, Ohno T, Ishii A, Sunnarborg SW, Okumura K, Saito H, Nakae S.
    • Journal Title

      Allergol Int. 59(2)

      Pages: 207-11

    • Related Report
      2009 Final Research Report
  • [Journal Article] 重症/難治性喘息の多様性とこれからの研究戦略2010

    • Author(s)
      大保木啓介、斎藤博久、中江進
    • Journal Title

      IgE practice in asthma 4(2)

      Pages: 2-5

    • Related Report
      2009 Final Research Report
  • [Journal Article] マスト細胞による免疫調節機序(特集アレルギーの促進要因と抑制要因)2010

    • Author(s)
      大保木啓介、大野建州、梶原直樹、斎藤博久、中江進
    • Journal Title

      臨床免疫・アレルギー科 53(1)

      Pages: 29-35

    • NAID

      40016992917

    • Related Report
      2009 Final Research Report
  • [Journal Article] Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages.2009

    • Author(s)
      Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S.
    • Journal Title

      J Immunol. 183(12)

      Pages: 7890-7

    • Related Report
      2009 Final Research Report
  • [Journal Article] Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction.2009

    • Author(s)
      Nishida K, Hasegawa A, Nakae S, Oboki K, Saito H, Yamasaki S, Hirano T.
    • Journal Title

      J Exp Med. 206(6)

      Pages: 1351-64

    • Related Report
      2009 Final Research Report
  • [Journal Article] IL-33によるマスト細胞の活性化2009

    • Author(s)
      大野建州、大保木啓介、梶原直樹、斎藤博久、中江進
    • Journal Title

      臨床免疫・アレルギー 52(1)

      Pages: 93-99

    • NAID

      40016715341

    • Related Report
      2009 Final Research Report
  • [Journal Article] マスト細胞とTh17細胞とによるアレルギー2009

    • Author(s)
      梶原直樹、大保木啓介、大野建州、斎藤博久、中江進
    • Journal Title

      臨床免疫・アレルギー科 52(1)

      Pages: 119-129

    • NAID

      40016715344

    • Related Report
      2009 Final Research Report
  • [Journal Article] IL-33とアレルギー2009

    • Author(s)
      大保木啓介、大野建州、梶原直樹、斎藤博久、中江進
    • Journal Title

      実験医学別冊 27(20)

      Pages: 126-131

    • Related Report
      2009 Final Research Report
  • [Journal Article] Th17細胞とアレルギー2009

    • Author(s)
      梶原直樹、大保木啓介、大野建州、斎藤博久、中江進
    • Journal Title

      実験医学別冊 27(20)

      Pages: 36-42

    • Related Report
      2009 Final Research Report
  • [Journal Article] Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction.2009

    • Author(s)
      Nishida K, Hasegawa A, Nakae S, Oboki K, Saito H, Yamasaki S, Hirano T.
    • Journal Title

      J Exp Med. 206

      Pages: 1351-64

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caspase-1, caspase-8, and calpain are dispensable for IL-33 release bymacrophages.2009

    • Author(s)
      Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S.
    • Journal Title

      J Immunol. 183

      Pages: 7890-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-33によるマスト細胞の活性化2009

    • Author(s)
      大野建州、大保木啓介、梶原直樹、斎藤博久、中江進
    • Journal Title

      臨床免疫・アレルギー科 52

      Pages: 93-99

    • NAID

      40016715341

    • Related Report
      2009 Annual Research Report
  • [Journal Article] マスト細胞とTh17細胞とによるアレルギー2009

    • Author(s)
      梶原直樹、大保木啓介、大野建州、斎藤博久、中江進
    • Journal Title

      臨床免疫・アレルギー科 52

      Pages: 119-129

    • NAID

      40016715344

    • Related Report
      2009 Annual Research Report
  • [Journal Article] マスト細胞による免疫調節機序(特集アレルギーの促進要因と抑制要因)2009

    • Author(s)
      大保木啓介、大野建州、梶原直樹、斎藤博久、中江進
    • Journal Title

      臨床免疫・アレルレギー科 53

      Pages: 29-35

    • NAID

      40016992917

    • Related Report
      2009 Annual Research Report
  • [Journal Article] IL-33とアレルギー2009

    • Author(s)
      大保木啓介、大野建州、梶原直樹、斎藤博久、中江進
    • Journal Title

      実験医学増刊(アレルギー疾患の免疫機構) 27

      Pages: 3322-27

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Th17細胞とアレルギー2009

    • Author(s)
      梶原直樹、大保木啓介、大野建州、斎藤博久、中江進
    • Journal Title

      実験医学増刊(アレルギー疾患の免疫機構) 27

      Pages: 3232-38

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Mast cells and T-cell expansion.2008

    • Author(s)
      Nakae, S., Oboki, K., Saito, H.
    • Journal Title

      Blood 111

      Pages: 2497-2498

    • Related Report
      2009 Final Research Report
  • [Journal Article] IL- 17およびTh17細胞による免疫応答2008

    • Author(s)
      大野建州、大保木啓介、梶原直樹、斎藤博久、中江進
    • Journal Title

      Minophagen Medical Review 53(5/6)

      Pages: 261-290

    • Related Report
      2009 Final Research Report
  • [Journal Article] アレルギー疾患とIL-17/Th17細胞-アレルギー・疾患の発症機構におけるIL-17およびTh17細胞の役割2008

    • Author(s)
      大保木啓介大野建州斎藤博久中江進
    • Journal Title

      医学のあゆみ 226(4)

      Pages: 281-289

    • Related Report
      2009 Final Research Report
  • [Journal Article] Th17誘導性気道炎症とマスト細胞(特集免 疫学の最近の動向)2008

    • Author(s)
      大保木啓介、大野建州、斎藤博久、中江進
    • Journal Title

      生体の科学 59(4)

      Pages: 281-289

    • NAID

      40016204561

    • Related Report
      2009 Final Research Report
  • [Journal Article] Mast cells and T-cell expansion2008

    • Author(s)
      Nakae S, Oboki K and Saito H.
    • Journal Title

      Blood 111

      Pages: 2497-2498

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Th17 and allergy2008

    • Author(s)
      Oboki, K., Ohno, T., Saito, H. Nakae
    • Journal Title

      Allergology International 57

      Pages: 121-134

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells.2007

    • Author(s)
      Hijikata A, Kitamura H, Kimura Y, Yokoyama R, Aiba Y, Bao Y, Fujita S, Hase K, Hori S, Ishii Y, Kanagawa O, Kawamoto H, Kawano K, Koseki H, Kubo M, Kurita-Miki A, Kurosaki T, Masuda K, Nakata M, Oboki K, Ohno H, Okamoto M, Okayama Y, O-Wang J, Saito H, Saito T, Sakuma M, Sato K, Sato K, Seino K,Setoguchi R, Tamura Y, Tanaka M, Taniguchi M, Taniuchi I, Teng A, Watanabe T, Watarai H, Yamasaki S, Ohara O.
    • Journal Title

      Bioinformatics. 23(21)

      Pages: 2934-41

    • Related Report
      2009 Final Research Report
  • [Journal Article] Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression.

    • Author(s)
      Ishii A, Oboki K, Nambu A, Morita H, Ohno T, Kajiwara N, Arae K, Sudo H, Okumura K, Saito H, Nakae S.
    • Journal Title

      Allergol Int. (in press)

    • Related Report
      2009 Final Research Report
  • [Presentation] Regulatory T cell expansion by IL-33-primed mast cells is crucial for immunosuppression.2008

    • Author(s)
      大保木啓介, 他
    • Organizer
      第38回日本免疫学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-12-01
    • Related Report
      2009 Final Research Report
  • [Presentation] Regulatory T cell expansion by IL-33-primed mast cells is crucial for imraunosuppression2008

    • Author(s)
      大保木啓介
    • Organizer
      日本免疫学会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 制御性T細胞の製造方法2010

    • Inventor(s)
      中江進、大保木啓介、大野建州、山田倫子、梶原直樹、斎藤博久
    • Industrial Property Rights Holder
      財団法人ヒューマンサイエンス振興財団
    • Filing Date
      2010-01-14
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 制御性T細胞の製造方法2008

    • Inventor(s)
      中江進、大保木啓介、大野建州、山田倫子、梶原直樹、斎藤博久
    • Industrial Property Rights Holder
      ヒューマンサイエンス振興財団
    • Filing Date
      2008-06-30
    • Acquisition Date
      2008-06-30
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 制御性T細胞の製造方法2008

    • Inventor(s)
      中江進、大保木啓介
    • Industrial Property Rights Holder
      国立成育医療センター
    • Filing Date
      2008-06-30
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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