Effect of staphylococcal gene distracting host-immune system on atopic dermatitis

• Project/Area Number: 20790711
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Infectious disease medicine
• Research Institution: Juntendo University
• Principal Investigator: KATAYAMA Yuki Juntendo University, 医学部, 助教 (60365591)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 黄色ブドウ球菌 / 皮膚炎発症マウスモデル / ゲノムアイランド / 病原性遺伝子群 / β溶血毒素 / 皮膚定着因子 / MHCホモログ遺伝子

Research Abstract

Effect of staphylococcal gene distracting host-immune system on atopic dermatitis

Research Products

• [Journal Article] Heterogeneously vancomycin-intermediate Staphylococcus aureus (hVISA) emerged before the clinical introduction of vancomycin in Japan : A retrospective study. (2011)
  • Author(s): Jun Yamakawa, Mayumi Aminaka, Katsuko Okuzumi, Hiroyoshi Kobayashi, Yuki Katayama, Shigemi Kondo, Ayako Nakamura, Toyoko Oguri, Satoshi Hori, Longzhu Cui, Teruyo Ito, Jingxun Jin, Hisashi Kurosawa, Kazuo Kaneko, Keiichi Hiramatsu.
  • Journal Title: Journal of Clinical Microbiology, Submitted.
  • NAID: 10030787468
  • Peer Reviewed
• [Journal Article] Impact of RpoB mutations on decreased susceptibility to vancomycin in Staphylococcus aureus. (2011)
  • Author(s): Watanabe, Y., Cui, L., Katayama, Y., Kishii, K., Hiramatsu, K.
  • Journal Title: Journal of Clinical Microbiology.
  • Peer Reviewed
• [Journal Article] MHC analogues found in Staphylococcus aureus affect phagocytosis and other immune responses by human white-blood cells. (2011)
  • Author(s): Sekine, M., T.Baba, Y.Katayama, Y., Hiramatsu, K
  • Journal Title: Juntendo Medical Journal. Volume: 57 Pages: 232-242
  • NAID: 10029499381
  • Peer Reviewed
• [Journal Article] Impact of RpoB mutations on decreased susceptibility to vancomycin in Staphylococcus aureus. (2011)
  • Author(s): Watanabe, Y., Cui, L., Katayama, Y., Kishii, K., Hiramatsu, K.
  • Journal Title: Journal of Clinical Microbiology Volume: 49 Pages: 2680-4
  • Peer Reviewed
• [Journal Article] Mutation of RNA polymerase beta-subunit (rpoB) promotes vancomycin resistance in Staphylococcus aureus. (2011)
  • Author(s): Matsuo, M., Hishinuma, T., Katayama, Y., Cui, L., Kapi, M., Hiramatsu, K.
  • Journal Title: Antimicrobial Agents and Chemotherapy Volume: 55 Pages: 4188-95
  • Peer Reviewed
• [Journal Article] The mechanisms of resistance to vancomycin. (2010)
  • Author(s): Katayama, Y., Hiramatsu, K.
  • Journal Title: Rinsho Kensa 54 Pages: 481-487
  • NAID: 40017090885
  • Peer Reviewed
• [Journal Article] MHC analogues found in Staphylococcus aureus affect phagocytosis and other immune responses by human white-blood cells. (2010)
  • Author(s): Sekine, M., T.Baba, Y.Katayama, Y.Hiramatsu, K.
  • Journal Title: Juntendo Medical Journal.
  • NAID: 10029499381
  • Peer Reviewed
• [Journal Article] The mechanisms of resistance to vancomycin. (2010)
  • Author(s): Katayama, Y., Hiramatsu, K.
  • Journal Title: Rinsho Kensa Volume: 54 Pages: 481-7
  • NAID: 40017090885
• [Journal Article] Heterogeneously vancomycin-intermediate Staphylococcus aureus (hVISA) emerged before the clinical introduction of vancomycin in Japan : A retrospective study. (2010)
  • Author(s): Jun Yamakawa1,2, Mayumi Aminaka2, Katsuko Okuzumi 3, Hiroyoshi Kobayashi 4, Yuki Katayama5, Shigemi Kondo6, Ayako Nakamura6, Toyoko Oguri6+, Satoshi Hori2, Longzhu Cui2,5, Teruyo Ito2,5, Jingxun Jin2, Hisashi Kurosawa1, Kazuo Kaneko1, Keiichi Hiramatsu.
  • Journal Title: Journal of Infection and Chemotherapy
  • NAID: 10030787468
  • Peer Reviewed
• [Journal Article] Selection of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus by Imipenem. (2009)
  • Author(s): Katayama, Y., H.Kuroda-Murakami, K.Hiramatsu.
  • Journal Title: Antimicrobial Agents and Chemotherapy. 53 Pages: 3190-3196
  • Peer Reviewed
• [Journal Article] Selection of Heterogeneous Vancomycin-Intermediate Staphylococcusaureus by lmipenem (2009)
  • Author(s): Yuki Katayama, Hiroko Murakami-Kuroda, Longzhu Cui, Keiichi Hiramatsu.
  • Journal Title: Antimicrob Agents Chemother 53 Pages: 3190-3196
  • Peer Reviewed
• [Journal Article] The effects of antibiotics on the production of Panton-Valentine leukocidin (PVL) in Staphylococcus aureus. (2008)
  • Author(s): Morimoto, Y., Ito, T., Katayama, Y., Baba, T., Uchikawa, T., Ohishi, K., Hongo, I., Hiramatsu K.
  • Journal Title: Juntendo Medical Journal. 54 Pages: 480-491
  • Peer Reviewed
• [Journal Article] The effects of antibiotics on the production of Panton-Valentine leukocidin (PVL) in Staphylococcus aureus (2008)
  • Author(s): 森本ゆふ、伊藤輝代、片山由紀、馬場理、内川知美、大石金成、本郷勇、平松啓一
  • Journal Title: Juntendo medical Journal 54(4) Pages: 480-491
  • Peer Reviewed
• [Journal Article] Mutation of RNA polymerase &#x03B2 ; subunit (rpoB) promotes vancomycin resistance in Staphylococcus aureus.
  • Author(s): Matsuo, M., Hishinuma, T., Katayama, Y., Cui, L., Kapi, M., Hiramatsu, K.
  • Journal Title: mBio00293-10(2010), Submitted.
  • Peer Reviewed
• [Presentation] Complete reconstitution of vancomycin-intermediate resistance in a vancomycin-susceptible Staphylococcus aureus strain. (POSTER). (2011)
  • Author(s): Yuki Katayama, Tomomi Hishinuma, Miki Matsuo, Yoshifumi Aiba, Keiichi Hiramatsu.
  • Organizer: 8th International symposium on Antimicrobial Agents and Resistance (ISAAR)
  • Place of Presentation: Souel, Korea
• [Presentation] 種々の抗生物質暴露によるhVISA (Heterogeneous Vancomycin-Intermediate Staphylococcus aureus)の出現 (2010)
  • Author(s): 片山由紀、渡辺由希子、松尾美記、菱沼知美、山川潤、平松啓一
  • Organizer: 第58回日本化学療法学会総会(口頭)
  • Place of Presentation: 長崎
• [Presentation] Vancomycin感受性黄色ブドウ球菌(VSSA)株ΔIPにおける段階的Vancomycin耐性化機構の解析 (2010)
  • Author(s): 片山由紀、松尾美記、菱沼知美、渡辺由希子、平松啓一
  • Organizer: 第83回日本細菌学会総会(口頭)
  • Place of Presentation: 横浜
• [Presentation] 種々の抗生物質暴露によるhVISA(Heterogeneous Vancomycin-Intermediate Staphylococcus aureus)の出現 (2010)
  • Author(s): 片山由紀、渡辺由希子、松尾美記、菱沼知美、山川潤、平松啓一
  • Organizer: 第58回日本化学療法学会総会
  • Place of Presentation: 長崎
• [Presentation] Vancomycin感受性黄色ブドウ球菌(VSSA)株ΔIPにおける段階的Vancomycin耐性化機構の解析 (2010)
  • Author(s): 片山由紀、松尾美記、菱沼知美、渡辺由希子、平松啓一
  • Organizer: 第83回日本細菌学会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 黄色ブドウ球菌に存在するヒトMHC様分子の生理的機能の考察 (2010)
  • Author(s): 関根美和、馬場理、片山由紀、平松啓一
  • Organizer: 第83回日本細菌学会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 黄色ブドウ球菌ゲノムアイランドの病原性への関与について (2010)
  • Author(s): 馬場理、関根美和、片山由紀、平松啓一
  • Organizer: 第83回日本細菌学会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Imipenemによるヘテロバンコマイシン耐性黄色ブドウ球菌(Heterogeneous Vancomycin-Intermediate S.aureus ; hVISA)の選択 (2009)
  • Author(s): 片山由紀、黒田博子、崔龍洙、平松啓一
  • Organizer: 第57回日本化学療法学会総会(口頭)
  • Place of Presentation: 東京
• [Presentation] 黄色ブドウ球菌のマウス皮膚定着性への溶血毒素β-ヘモリジン(Hlb)の関与。細菌学雑誌 (2009)
  • Author(s): 片山由紀、関根美和、馬場理、平松啓一
  • Organizer: 第82回日本細菌学会総会vol.82
  • Place of Presentation: 名古屋
• [Presentation] Imipenemによるヘテロバンコマイシン耐性黄色ブドウ球菌(Heterogeneous Vancomycin-Intermediate S.aureus ; hVISA)の選択 (2009)
  • Author(s): 片山由紀、黒田博子、崔龍沫、平松啓一
  • Organizer: 第57回日本化学療法学会
  • Place of Presentation: ホテル日航東京
• [Presentation] 黄色ブドウ球菌のマウス皮膚定着性への溶血毒素β-ヘモリジン(Hlb)の関与 (2009)
  • Author(s): 片山由紀、関根美和、馬場理、平松啓一
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] 黄色ブドウ球菌特異的ゲノムアイランドの機能と宿主生物種特異的病原性 (2009)
  • Author(s): 馬場理・片山由紀・関根美和・関水和久・平松啓一
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] 黄色ブドウ球菌のヘテロバンコマイシン耐性を起こすTwo-component system vraSRの活性化について。細菌学雑誌 (2008)
  • Author(s): 片山由紀、黒田博子、平松啓一
  • Organizer: 第81回日本細菌学会総会vol.81.p152(口頭)
  • Place of Presentation: 京都
• [Book] 病原菌今日的意味(ブドウ球菌) (2010)
  • Author(s): Katayama, Y., Hiramatsu, K.
  • Publisher: 医薬ジャーナル社
• [Remarks]
  • URL: http://read.jst.go.jp/public/cs_ksh_008EventAction.do?action4=event&1ang_act4=J&jtdge_act4=2&knkysh-name_code=1000264301