Non-invasive evaluation of the pulmonary hypertension and inhibition of pulmonary vascular remodeling by bosentan.

• Project/Area Number: 20790716
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: Asahikawa Medical College
• Principal Investigator: SUGIMOTO Masaya Asahikawa Medical College, 医学部, 助教 (20400096)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 肺高血圧 / ボセンタン / リモデリング / シンチグラフィー

Research Abstract

We measured various kinds of blood biomarkers to evaluate the progression of pulmonary hypertension. Serum BNP and NT-proBNP which are known as heart failure marker were significantly increased in patients with pulmonary hypertension. PIIIP which is a marker of the myocardial collagen metabolism was increased by right ventricle pressure overload such as pulmonary hypertension. High sensitivity troponin I (cTnI) which is the most sensitive marker of the myocardial injury was significantly increased in patients with pulmonary hypertension. Furthermore, serum cTnI levels significantly correlated with pulmonary systemic blood pressure ratio (Pp/Ps).

Research Products

• [Journal Article] Volume overload and pressure overload due to left-to right shunt induced myocardial injury : evaluation using a highly sensitive cardiac troponin-I assay in children with congenital heart disease. (2011)
  • Author(s): Sugimoto M, Ota K, Kajino H
  • Journal Title: Circulation Journal in press
  • NAID: 10029339810
  • Peer Reviewed
• [Journal Article] 5.78 Mb terminal deletion of chromosome 15q in a girl, evaluation of NR2F2 as candidate gene for congenital heart defects. (2011)
  • Author(s): Nakamura E, Sugimoto M, Kajino H
  • Journal Title: Eur J Med Genet 54(3) Pages: 354-356
  • Peer Reviewed
• [Journal Article] The role of N-terminal pro B type natriuretic peptide (NT-proBNP) in the diagnosis of congestive heart failure in children : Correlation with the CHF grading score and comparison with BNP (2010)
  • Author(s): Sugimoto M, Manabe H, Kajino H
  • Journal Title: Circulation Journal 74 Pages: 998-1005
  • Peer Reviewed
• [Journal Article] The role of N-terminal pro B type natriuretic peptide in the diagnosis of congestive heart failure in children : Correlation with the heart failure score and comparison with BNP. (2010)
  • Author(s): Masaya Sugimoto
  • Journal Title: Circulation Journal Volume: 74 Pages: 998-1005
  • Peer Reviewed
• [Journal Article] High serum levels of procollagen type III N-terminal amino peptide in patients with congenital heart disease. (2009)
  • Author(s): Sugimoto M, Kajino H, Senzaki H
  • Journal Title: Heart 95(24) Pages: 2023-2028
  • Peer Reviewed
• [Journal Article] High serum levels of procollagen type III N-terminal aminopeptide in patients with congenital heart disease (2009)
  • Author(s): Masaya Sugimoto
  • Journal Title: Heart Volume: 95 Pages: 2023-2028
  • Peer Reviewed
• [Presentation] Pulmonary hypertension-induced myocardial injury : Evaluation using a highly sensitive cardiac troponin-I assay in children with congenital heart disease. (2010)
  • Author(s): Masaya Sugimoto
  • Organizer: AHA scientific sessions 2010
  • Place of Presentation: シカゴ
  • Year and Date: 2010-11-17
• [Presentation] Pulmonary hypertension causes myocardial injury : evaluation using a highly sensitive cardiac troponin-I assay in children with congenital heart disease. (2010)
  • Author(s): Sugimoto M, Kajino H
  • Organizer: AHA scientific sessions 2010
  • Place of Presentation: Chicago, US
  • Year and Date: 2010-11-15
• [Presentation] 心室中隔欠損患者において血中高感度心筋トロポニンI値は肺高血圧の程度を反映する (2010)
  • Author(s): 杉本昌也, 梶野浩樹, 藤枝憲二
  • Organizer: 第46回日本小児循環器学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-10
• [Presentation] Left and Right ventricular-vascular pathophysiology after arterial switch operation (2010)
  • Author(s): Sugimoto M, Senzaki H, Kajino H
  • Organizer: 第46回日本小児循環器学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-10
• [Presentation] Serum Levels of Procollagen Type III-N-terminal Amino Peptide (PIIIP) in Patients with Single Ventricular Circulation (2010)
  • Author(s): Sugimoto M, Senzaki H, Kajino H
  • Organizer: 第46回日本小児循環器学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-10
• [Presentation] Pulmonary hypertension increases highly sensitive cardiac troponin-I levels : a comparison between children with ventricular septal defects and children with atrial septal defects. (2010)
  • Author(s): Sugimoto M, Kajino H
  • Organizer: XXth World Congress of the International Society for Heart Research
  • Place of Presentation: 京都
  • Year and Date: 2010-05-14
• [Presentation] Pulmonary hypertension increases highly sensitive serum cardiac troponin-I levels in children with ventricular septal defects (2010)
  • Author(s): Masaya Sugimoto
  • Organizer: XXth World Congress of the International Society for Heart Research 2010
  • Place of Presentation: 京都
  • Year and Date: 2010-05-14
• [Presentation] Pulmonary hypertension increases serum cardiac troponin-I levels in children with ventricular septal defects. (2010)
  • Author(s): Sugimoto M, Kajino H
  • Organizer: 2010 Pediatric Academic Societies' Annual Meeting
  • Place of Presentation: Vancouver
  • Year and Date: 2010-05-03
• [Presentation] Pulmonary hypertension increases serum cardiac troponin-I levels in children with ventricular septal defects (2010)
  • Author(s): Masaya Sugimoto
  • Organizer: 2010 Pediatric Academic Societies' Annual Meeting
  • Place of Presentation: バンクーバー
  • Year and Date: 2010-05-03
• [Presentation] One and a half ventricular repair後の上大静脈の血行動態の評価 (2009)
  • Author(s): 杉本昌也, 梶野浩樹, 藤枝憲二
  • Organizer: 第45回日本小児循環器学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2009-07-16
• [Presentation] Serum N-terminal pro-brain natriuretic peptide reflects the grade of congestive heart failure in children. (2008)
  • Author(s): Sugimoto M, Kajino H, Fujieda K
  • Organizer: AHA scientific sessions 2008
  • Place of Presentation: New Orleans, US
  • Year and Date: 2008-11-11
• [Presentation] 先天性心疾患の診療における心臓バイオマーカーの有用性 (2008)
  • Author(s): 杉本昌也, 梶野浩樹, 藤枝憲二
  • Organizer: 第44回日本小児循環器学会学術集会
  • Place of Presentation: 郡山
  • Year and Date: 2008-07-09
• [Presentation] 先天性心疾患の病態と心臓バイオマーカーの関係 (2008)
  • Author(s): 杉本昌也, 梶野浩樹, 藤枝憲二
  • Organizer: 第111回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-04-26
• [Book] 小児・新生児診療ゴールデンハンドブック (2009)
  • Author(s): 杉本昌也、梶野浩樹、藤枝憲二, 他共著
  • Publisher: 南江堂