The structure based drug design for controlling the innate immune response and interleukin-18 signaling.

• Project/Area Number: 20790723
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: Gifu University
• Principal Investigator: OHNISHI Hidenori Gifu University, 医学部附属病院, 助教 (60381620)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 自然免疫 / IL-18 / Toll-like receptor / MyD88 / タンパク立体構造 / 創薬 / Toll-like recetor

Research Abstract

MyD88 is the important adaptor molecule in the Toll like receptors and IL-1/18 signaling pathways. In this study, we tried to create the molecule, which regulate these immune signaling response, based on the results of our decided protein structure of MyD88 and protein interaction studies. In the duration of this research aid, we could develop the several methods of direct protein-protein interaction studies with the TIR domain containing molecules. Furthermore, we created the new molecule, protein transduction domain containing dominant negative formed MyD88 (PTD-MyD88-DN). We will continue the drug development that assumed MyD88 a target.

Research Products

• [Journal Article] Genetic variations in MyD88 adaptor-like are associated with atopic dermatitis. (2011)
  • Author(s): An Y, Ohnishi H, Matsui E, Funato M, Kato Z, Teramoto T, Kaneko H, Kimura T, Kubota K, Kasahara K, Kondo N.
  • Journal Title: Int J Mol Med. 27(6) Pages: 795-801
  • NAID: 120006341946
  • Peer Reviewed
• [Journal Article] Antigen-specific immune response to endotoxin-free recombinant P34 (2011)
  • Author(s): Morita H, Kaneko H, Ohnishi H, Kato Z, Kondo N.
  • Journal Title: .Allergy.
  • Peer Reviewed
• [Journal Article] Genetic variations in MyD88 adaptor-like are associated with atopic dermatitis. (2011)
  • Author(s): Yang An, Hidenori Ohnishi, Eiko Matsui, Michinori Funato, Zenichiro Kato, Takahide Teramoto, Hideo Kaneko, Takeshi Kimura, Kazuo Kubota, Kimiko Kasahara, Naomi Kondo.
  • Journal Title: Int J Mol Med Volume: 27 Pages: 795-801
  • NAID: 120006341946
  • Peer Reviewed
• [Journal Article] Antigen-specific immune response to endotoxin-free recombinant P34. (2011)
  • Author(s): Morita H, Kaneko H, Ohnishi H, Kato Z, Kondo N.
  • Journal Title: Allergy Volume: (E Pub)
  • Peer Reviewed
• [Journal Article] Efficacy of the slow dose-up method for specific oral tolerance induction in children with cow's milk allergy : comparison with reported protocols. (2010)
  • Author(s): Kaneko H, Teramoto T, Kondo M, Morita H, Ohnishi H, Orii K, Matsui E, Kondo N.
  • Journal Title: J Investig Allergol Clin Immunol. 20(6) Pages: 538-539
  • Peer Reviewed
• [Journal Article] Mutation in the Q28SDD31SD site, but not in the two SQ sites of the survival of motor neuron protein, affects its foci formation. (2010)
  • Author(s): Aoki Y, Fukao T, Zhang G, Ohnishi H, Kondo N.
  • Journal Title: Int J Mol Med. 26(5) Pages: 667-671
  • NAID: 120006341937
  • Peer Reviewed
• [Journal Article] Interleukin-17 expression in the urticarial rash of familial cold autoinflammatory syndrome : a case report. (2010)
  • Author(s): Yamauchi A, Iwata H, Ohnishi H, Teramoto T, Kondo N, Seishima M.
  • Journal Title: Br J Dermatol. 163(6) Pages: 1351-1353
  • Peer Reviewed
• [Journal Article] 1H, 13C, and 15N resonance assignment of the TIR domain of human MyD88. (2010)
  • Author(s): Ohnishi H, Tochio H, Kato Z, Kimura T, Hiroaki H, Kondo N, Shirakawa M.
  • Journal Title: Biomol NMR Assign. 4(2) Pages: 123-125
  • NAID: 120002709551
  • Peer Reviewed
• [Journal Article] Prediction of the pathogenesis of the mutation in MeCP2 C-terminal domain. (2010)
  • Author(s): Kato Z, Ohnishi H, Kimura T, Kondo N.
  • Journal Title: Brain Dev. 32(2) Pages: 169-169
  • NAID: 10027213098
  • Peer Reviewed
• [Journal Article] Interleukin-17 expression in the urticarial rash of familial cold autoinflammatory syndrome : a case report. (2010)
  • Author(s): Yamauchi A, Iwata H, Ohnishi H, Teramoto T, Kondo N, Seishima M.
  • Journal Title: Br J Dermatol Volume: 163 Pages: 1351-1353
  • Peer Reviewed
• [Journal Article] Efficacy of the slow dose-up method for specific oral tolerance induction in children with cow's milk allergy : comparison with reported protocols. (2010)
  • Author(s): Kaneko H, Teramoto T, Kondo M, Morita H, Ohnishi H, Orii K, Matsui E, Kondo N.
  • Journal Title: J Investig Allergol Clin Immunol Volume: 20 Pages: 538-539
  • Peer Reviewed
• [Journal Article] Mutation in the Q28SDD31SD site, but not in the two SQ sites of the survival of motor neuron protein, affects its foci formation. (2010)
  • Author(s): Aoki Y, Fukao T, Zhang G, Ohnishi H, Kondo N.
  • Journal Title: Int J Mol Med Volume: 26 Pages: 667-671
  • NAID: 120006341937
  • Peer Reviewed
• [Journal Article] (1)H, (13)C, and (15)N resonance assignment of the TIR domain of human MyD88. (2010)
  • Author(s): Ohnishi H, Tochio H, Kato Z, Kimura T, Hiroaki H, Kondo N, Shirakawa M.
  • Journal Title: Biomol NMR Assign.
  • NAID: 120002709551
  • Peer Reviewed
• [Journal Article] Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling. (2009)
  • Author(s): Ohnishi H, Tochio H, Kato Z, Orii KE, Li A, Kimura T, Hiroaki H, Kondo N, Shirakawa M.
  • Journal Title: Proc Natl Acad Sci USA. 106(25) Pages: 10260-10265
  • Peer Reviewed
• [Journal Article] Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling. (2009)
  • Author(s): Ohnishi H, Tochio H, Kato Z, Orii KE, Li A, Kimura T, Hiroaki H, Kondo N, Shirakawa M.
  • Journal Title: Proc Natl Acad Sci USA. 106 Pages: 10260-10265
  • Peer Reviewed
• [Journal Article] 免疫不全とアレルギー-特に,自然免疫系の分子のタンパク構造生物学的視点から- (2009)
  • Author(s): 近藤直実、大西秀典、加藤善一郎、松井永子、木村豪、徳見哲司、森田秀行、金子英雄、寺本貴英
  • Journal Title: 日本小児アレルギー学会誌 23 Pages: 203-211
  • NAID: 10026284582
• [Journal Article] 自然免疫の分子機構に基づいた自己炎症性症候群の診断へのアプローチ (2009)
  • Author(s): 大西秀典、加藤善一郎、寺本貴英、舩戸道徳、金子英雄、深尾敏幸、近藤直実
  • Journal Title: アレルギー 58 Pages: 1502-1512
  • NAID: 110007482487
  • Peer Reviewed
• [Journal Article] 自然免疫系の障害による原発性免疫不全症の最近の動向 (2009)
  • Author(s): 徳見哲司、大西秀典、金子英雄、加藤善一郎、近藤直実
  • Journal Title: アレルギー 58 Pages: 19-28
  • Peer Reviewed
• [Journal Article] 感染症・免疫異常の臨床遺伝学 (2009)
  • Author(s): 近藤直実、大西秀典、徳見哲司、金子英雄、加藤善一郎
  • Journal Title: 小児科臨床 1 Pages: 77-82
• [Journal Article] Expression, purification and structural analysis of human IL-18 binding protein : a potent therapeutic molecule for allergy. (2008)
  • Author(s): Kimura T, Kato Z, Ohnishi H, Tochio H, Shirakawa M, Kondo N.
  • Journal Title: Allergol Int. 57(4) Pages: 367-376
  • NAID: 10025108541
  • Peer Reviewed
• [Journal Article] Hypothermia augments NF-kappaB activity and the production of IL-12 and IFN-gamma. (2008)
  • Author(s): Arai T, Kaneko H, Ohnishi H, Matsui E, Fukao T, Kawamoto N, Kasahara K, Kondo N.
  • Journal Title: Allergol Int. 57(4) Pages: 331-338
  • NAID: 10025108414
  • Peer Reviewed
• [Journal Article] A novel polymorphism, E254K, in the 5-lipoxygenase gene associated with bronchial asthma. (2008)
  • Author(s): Bai C, Matsui E, Ohnishi H, Kimata K, Kasahara K, Kaneko H, Kato Z, Fukao T, Kondo N.
  • Journal Title: Int J Mol Med. 21(2) Pages: 139-144
  • NAID: 120006340784
  • Peer Reviewed
• [Journal Article] Expression, Purification and Structural Analysis of Human IL-18 Binding Protein : A Potent Therapeutlic Molecule for Allergy (2008)
  • Author(s): T Kimura, Z Kato, H Ohnishi, H Tochio, M Shirakawa, N Kondo
  • Journal Title: Allergol Int 57 Pages: 367-376
  • Peer Reviewed
• [Journal Article] Hypothermia Augments NF-kappaB Activity and the Production of IL-12 and IFN-gamma (2008)
  • Author(s): T Arai, H Kaneko, H Ohnishi, E Matsui, T Fukao, N Kawamoto, K Kasahara, N Kondo
  • Journal Title: Allergol Int 57 Pages: 331-338
  • NAID: 10025108414
  • Peer Reviewed
• [Journal Article] 小児インフルエンザにおける麻黄湯の効果と治療の選択についての検討 (2008)
  • Author(s): 福富悌, 金子英雄, 大西秀典, 笠原貴美子, 近藤直実
  • Journal Title: 漢方と免疫・アレルギー 27 Pages: 22-33
  • Peer Reviewed
• [Journal Article] 小児気管支喘息患児と親又は保護者のQOL調査票簡易改訂版2008(GIFU) (2008)
  • Author(s): 近藤直実, 平山耕一郎, 松井永子, 寺本貴英, 金子英雄, 深尾敏幸, 折居建治, 川本美奈子, 舩戸道徳, 大西秀典, 川本典生, 森田秀行, 木村豪, 名田匡利, 徳見哲司, 堀友博, 渡邊倫子
  • Journal Title: アレルギー 57 Pages: 1022-1033
  • NAID: 110006884769
  • Peer Reviewed
• [Journal Article] 免疫寛容誘導のための食物アレルギー主要抗原タンパクの基礎的検討 (2008)
  • Author(s): 森田秀行、金子英雄、大西秀典、近藤應、松井永子、深尾敏幸、近藤直実
  • Journal Title: 日本小児アレルギー学会誌 22 Pages: 233-238
  • NAID: 10026940238
• [Presentation] 自然免疫異常症の構造生物学的解析 (2010)
  • Author(s): 大西秀典、加藤善一郎、木村豪、久保田一生、金子英雄、近藤直実、堤尚孝、杤尾豪人、白川昌宏
  • Organizer: 第46回中部小児科学会
  • Place of Presentation: 金沢
  • Year and Date: 2010-08-22
• [Presentation] 最近、当科で診断した自己炎症性症候群の7例について (2010)
  • Author(s): 大西秀典、寺本貴英、加藤善一郎、松井永子、金子英雄、近藤直実、岩田浩明、加納宏行
  • Organizer: 第三回日本免疫不全症研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-30
• [Presentation] The genetic variations of the MyD88 adaptor protein like (Mal) are associated with allergic diseases in Japanese population. (2010)
  • Author(s): Hidenori Ohnishi, Yang An, Eiko Matsui, Zenichiro Kato, Hideo Kaneko, Naomi Kondo.
  • Organizer: The 20th Interasma Japan/North Asia.
  • Place of Presentation: Tokyo.
• [Presentation] Structural basis for the interactions of the MyD88 TIR domain in TLR4 signaling. (2010)
  • Author(s): Hidenori Ohnishi, Hidehito Tochio, ZenichiroKato, Takeshi Kimura, Naomi Kondo, Masahiro Shirakawa.
  • Organizer: World wide magnetic resonance conference 2010.
  • Place of Presentation: Florence, Italy.
• [Presentation] A conserved interaction mode between MyD88 and distinct membrane-sorting adaptors in TLR4 and IL-18 signaling. (2010)
  • Author(s): H.Ohnishi, H.Tochio, Z.Kato, T.Kimura, T.Funasaka, R.W.Wong, M.Shirakawa, N.Kondo.
  • Organizer: 14th International Congress of Immunology.
  • Place of Presentation: Kobe.
• [Presentation] The LPS induced enhancement of IL-1β and IL-18 production is a useful tool for diagnosis of familial cold inflammatory syndrome (FCAS). (2010)
  • Author(s): Hidenori Ohnishi, Takahide Teramoto, Zenichiro Kato, Hideo Kaneko, Ryuta Nishikomori, Naomi Kondo.
  • Organizer: Autoinflammation 2010.
  • Place of Presentation: Amsterdam, Netherlands.
• [Presentation] Structural basis for the innate immune deficiency syndrome. (2010)
  • Author(s): Hidenori Ohnishi, Hidehito Tochio, Zenichiro Kato, Takeshi Kimura, Masatoshi Nada, Kazuo Kubota, Masahiro Shirakawa, Naomi Kondo.
  • Organizer: The 8th Asia Pacific Congress of Allergy, Asthma and Clinical Immunology 2010.
  • Place of Presentation: Singapore.
• [Presentation] 乳児栄養の役割:母乳・人工乳 (2010)
  • Author(s): 大西秀典、金子英雄、森田秀行、川本美奈子、松井永子、加藤善一郎、近藤直実
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 盛岡
• [Presentation] 自然免疫異常症、アレルギー疾患病態解明に向けたプロテオミクス的手法の応用 (2010)
  • Author(s): 大西秀典、加藤善一郎、木村豪、安陽、久保田一生、松井永子、金子英雄、近藤直実
  • Organizer: 第47回日本小児アレルギー学会
  • Place of Presentation: 横浜
• [Presentation] The genetic variations of the MyD88 adaptor protein like (Ma1) are associated with allergic diseases in Japanese population. (2010)
  • Author(s): Hidenori Ohnishi, Yang An, Eiko Matsui, Zenichiro Kato, Hideo Kaneko, Naomi Kondo.
  • Organizer: The 20th Interasma Japan/North Asia
  • Place of Presentation: Tokyo
• [Presentation] Structural basis for the interactions of the MyD88 TIR domain in TLR4 signaling. (2010)
  • Author(s): Hidenori Ohnishi, Hidehito Tochio, Zenichiro Kato, Takeshi Kimura, Naomi Kondo, Masahiro Shirakawa.
  • Organizer: World wide magnetic resonance conference 2010
  • Place of Presentation: Florence, Italy
• [Presentation] A conserved interaction mode between MyD88 and distinct membrane-sorting adaptors in TLR4 and IL-18 signaling. (2010)
  • Author(s): H.Ohnishi, H.Tochio, Z.Kato, T.Kimura, T.Funasaka, R.W.Wong, M.Shirakawa, N.Kondo.
  • Organizer: 14th International Congress of Immunology.
  • Place of Presentation: Kobe
• [Presentation] The LPS induced enhancement of IL-1β and IL-18 production is a useful tool for diagnos is of familial cold inflammatory syndrome (FCAS). (2010)
  • Author(s): Hidenori Ohnishi, Takahide Teramoto, Zenichiro Kato, Hideo Kaneko, Ryuta Nishikomori, Naomi Kondo.
  • Organizer: Autoinflammation 2010
  • Place of Presentation: Amsterdam, Netherlands
• [Presentation] Structural basis for the innate immune deficiency syndrome. (2010)
  • Author(s): Hidenori Ohnishi, Hidehito Tochio, Zenichiro Kato, Takeshi Kimura, Masatoshi Nada, Kazuo Kubota, Masahiro Shirakawa, Naomi Kondo.
  • Organizer: The 8th Asia Pacific Congress of Allergy, Asthma and Clinical Immunology 2010
  • Place of Presentation: Singapore
• [Presentation] 自然免疫不全症(MyD88欠損症,IRAK4欠損症)の構造生物学的解析 (2010)
  • Author(s): 大西秀典、加藤善一郎、安陽、松井永子、金子英雄、近藤直実
  • Organizer: 第60回日本アレルギー学会秋期学術集会
  • Place of Presentation: 東京
• [Presentation] 化膿性細菌感染に関与するToll様受容体の細胞内シグナル伝達機構の構造生物学的解析 (2009)
  • Author(s): 大西秀典, 加藤善一郎, 木村豪, 名田匡利, 徳見哲司, 長屋聡一郎, 金子英雄, 近藤直実
  • Organizer: 第12回岐阜小児感染症懇話会
  • Place of Presentation: 岐阜
  • Year and Date: 2009-02-07
• [Presentation] 化膿性細菌感染に関与するToll様受容体の細胞内シグナル伝達機構の構造生物学的解析 (2009)
  • Author(s): 大西秀典, 加藤善一郎, 木村豪, 名田匡利, 徳見哲司, 長屋聡一郎, 金子英雄, 近藤直実
  • Organizer: 第二回日本免疫不全症研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-01-31
• [Presentation] MyD88免疫不全症におけるシグナル伝達機構の構造生物学的基盤解析 (2009)
  • Author(s): 加藤善一郎, 大西秀典, 木村豪, 徳見哲司, 名田匡利, 長屋聡一郎, 金子英雄, 近藤直実
  • Organizer: 第二回日本免疫不全症研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-01-31
• [Presentation] 化膿性細菌感染に関与するToll様受容体の細胞内シグナル伝達機構の構造生物学的解析 (2009)
  • Author(s): 大西秀典, 加藤善一郎, 木村豪, 名田匡利, 徳見哲司, 長屋聡一郎, 金子英雄, 近藤直実
  • Organizer: 第112回日本小児科学会学術集会
  • Place of Presentation: 奈良
• [Presentation] 自己炎症性症候群の包括的診断フローチャート(GIFU)に基づくCINCA症候群の診断例について (2009)
  • Author(s): 大西秀典、寺本貴英、川本典生、木村豪、加藤善一郎、金子英雄、深尾敏幸、近藤直実
  • Organizer: 第21回日本アレルギー学会春季臨床大会
  • Place of Presentation: 岐阜
• [Presentation] 家族性寒冷自己炎症症候群(FCAS)の分子生物学的解析 (2009)
  • Author(s): 大西秀典、寺本貴英、近藤直実、岩田浩明、青山裕美
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田
• [Presentation] 当科で経験したCIAS1遺伝子異常症4例の分子生物学的解析 (2009)
  • Author(s): 大西秀典、寺本貴英、加藤善一郎、木村豪、近藤直実、岩田浩明、青山裕美
  • Organizer: 第46回日本小児アレルギー学会
  • Place of Presentation: 福岡
• [Presentation] アレルギー発症にかかわる分子の構造学的解明と臨床応用 (2008)
  • Author(s): 大西秀典, 加藤善一郎, 木村豪, 徳見哲史, 福富悌, 近藤直実
  • Organizer: 第45回日本小児アレルギー学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-12-14
• [Presentation] 牛乳アレルギーにおける経口免疫寛容誘導食品の作成. ミニシンポジウム4食物アレルギー診療の新しい展開 (2008)
  • Author(s): 金子英雄, 森田秀行, 大西秀典, 近藤應, 川本美奈子, 松井永子, 深尾敏幸, 加藤晴彦, 中埜拓, 近藤直実
  • Organizer: 第45回日本小児アレルギー学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-12-14
• [Presentation] 母乳栄養とアレルギー疾患発症との関連について. シンポジウム3環境因子がアレルギー疾患の発症に及ぼす影響と発症予防の可能性について (2008)
  • Author(s): 川本美奈子, 大西秀典, 川本典生, 森田秀行, 松井永子, 金子英雄, 寺本貴英, 深尾敏幸, 白木誠, 岩砂眞一, 近藤直実
  • Organizer: 第45回日本小児アレルギー学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-12-13
• [Presentation] TLR4とIL-18シグナル伝達におけるMyD88と細胞膜誘導性アダプター分子の相互作用様式の解析 (2008)
  • Author(s): 大西秀典, 近藤直実
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] 大豆アレウギー寛容誘導を目的とするP34抗原修飾ペプチド作製に向けたBおよびT細胞反応性エピトープの解析 (2008)
  • Author(s): 森田秀行, 金子英雄, 大西秀典, 加藤善一郎, 松井永子, 深尾敏幸, 近藤直実
  • Organizer: 第58回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-29
• [Presentation] TLRシグナル伝達に関わるアダプター分子Malの機能解析とその臨床応用 (2008)
  • Author(s): 徳見哲司, 大西秀典, 加藤善一郎, 長屋聡一郎, 木村豪, 名田匡利, 金子英雄, 近藤直実
  • Organizer: 第58回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-27
• [Presentation] 細菌感染に関与するTLRの細胞内シグナル伝達機構の構造生物学的解析とその臨床応用 (2008)
  • Author(s): 大西秀典, 加藤善一郎, 福富悌, 木村豪, 名田匡利, 徳見哲司, 長屋聡一郎, 松井永子, 金子英雄, 近藤直実
  • Organizer: 第40回日本小児感染症学会総会・学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-16
• [Presentation] Expression, Purification and Structural Analysis of Human IL-18 Binding Protein : A Potent Therapeutic Molecule for Allergy (2008)
  • Author(s): Kimura T, Kato Z, Ohnishi H, Tokumi T, Tochio H, Shirakawa M, Konodo N
  • Organizer: Joint Singapore Paediatric Congress & APAPARI Meeting 2008
  • Place of Presentation: ンンガポール
  • Year and Date: 2008-10-03
• [Presentation] Molecular Analyses Of Interaction Between Myd88-Adaptor- Like And The Other TIR Proteins In Toll-Like Receptor Signaling (2008)
  • Author(s): Tokumi T, Ohnishi H, Kimura T, Kaneko H, Kondo N
  • Organizer: Joint Singapore Paediatric Congress & APAPARI Meeting 2008
  • Place of Presentation: ンンガポール
  • Year and Date: 2008-10-03
• [Presentation] グラム陽性菌感染に関与するTLRとアダプター分子間相互作用の構造生物学的解析とその臨床応用 (2008)
  • Author(s): 徳見哲司, 大西秀典, 加藤善一郎, 木村豪, 名田匡利, 金子英雄, 近藤直実
  • Organizer: 第44回中部日本小児科学会
  • Place of Presentation: 富山
  • Year and Date: 2008-08-24
• [Presentation] 母乳中のサイトカイン, 食物抗原とアレルギー発症との関連について (2008)
  • Author(s): 川本美奈子, 大西秀典, 川本典生, 森田秀行, 深尾敏幸, 金子英雄, 松井永子, 笠原貴美子, 近藤直実
  • Organizer: 第20回日本アレルギー学会春季臨床大会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-13
• [Presentation] 構造解析・臨床応用へ向けたIL-18結合タンパク大量発現系の構築 (2008)
  • Author(s): 木村豪, 加藤善一郎, 大西秀典, 李愛蓮, 近藤直実
  • Organizer: 第20回日本アレルギー学会春季臨床大会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-13
• [Presentation] 食物アレルギーにおけるβ-ラクトグロブリンおよび大豆P34分解ペプチドの臨床応用 (2008)
  • Author(s): 森田秀行, 金子英雄, 大西秀典, 近藤應, 松井永子, 深尾敏幸, 近藤直実
  • Organizer: 第20回日本アレルギー学会春季臨床大会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-12
• [Presentation] 脊髄性筋萎縮症の病態解析〜SMNタンパクのリン酸化に関する研究〜 (2008)
  • Author(s): 青木雄介, 深尾敏幸, 大西秀典, 折居建治, 近藤直実
  • Organizer: 第50回日本小児神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-28
• [Presentation] 食物アレルギーにおけるβ-ラクトグロブリンおよび大豆P34の分解ペプチドの臨床応用 (2008)
  • Author(s): 森田秀行, 金子英雄, 大西秀典, 近藤應, 川本美奈子, 松井永子, 深尾敏幸, 近藤直実
  • Organizer: 第111回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-04-27
• [Presentation] リポペプチドを認識するTLRとアダプター分子間相互作用の構造生物学的解析 (2008)
  • Author(s): 名田匡利, 大西秀典, 加藤善一郎, 李愛蓮, 徳見哲司, 相馬和佳, 金子英雄, 近藤直実
  • Organizer: 第111回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-04-27
• [Presentation] 母乳中のサイトカイン, 食物抗原とアレルギー発症との関連についての検討 (2008)
  • Author(s): 川本美奈子, 大西秀典, 川本典生, 森田秀行, 深尾敏幸, 金子英雄, 松井永子, 笠原貴美子, 近藤直実
  • Organizer: 第111回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-04-27
• [Presentation] アダプター分子MyD88のタンパク構造・機能解析とその創薬に向けた応用 (2008)
  • Author(s): 大西秀典, 加藤善一郎, 李愛蓮, 木村豪, 名田匡利, 徳見哲司, 長屋聡一郎, 相馬和佳, 近藤直実
  • Organizer: 第111回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-04-25
• [Presentation] Molecular analyses of protein-protein interactions of intra-cellular signaling in innate immunity. (英語口演) (2008)
  • Author(s): T Tokumi, H Ohnishi, Z Kato, S Nagaya, H Kaneko, N Kondo
  • Organizer: 第111回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-04-25
• [Presentation] 構造解析・臨床応用へ向けたIL-18結合タンパク大量発現系の構築 (2008)
  • Author(s): 木村豪, 加藤善一郎, 大西秀典, 李愛蓮, 近藤直実
  • Organizer: 第111回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-04-25
• [Book] Genetics of Pediatric Asthma.(Allergy Frontiers (volumel Allergy Frontiers : Epigenetics, Allergens and Risk Factors))(Pawankar R, Holgate ST, Rosenwasser LJ eds.) (2009)
  • Author(s): Kondo N, Matsui E, Kaneko H, Fukao T, Teramoto T, Kato Z, Ohnishi H, Nishimura A
  • Total Pages: 442
• [Book] Allergy Frontiers (volumel Allergy Frontiers : Epigenetics, Allergens and Risk Factors) (2009)
  • Author(s): Kondo N, Matsui E, Kaneko H, Fukao T, Teramoto T, Kato Z, Ohnishi H, Nishimura A : Genetics of Pediatric Asthma. In : Pawankar R, Holgate ST, Rosenwasser LJ eds
  • Total Pages: 442
  • Publisher: Springer
• [Remarks] ホームページ等
• [Patent(Industrial Property Rights)] 変異導入MyD88蛋白によるToll様受容体/インターロイキン18シグナルの特異的制御法 (2008)
  • Inventor(s): 近藤直実、加藤善一郎、大西秀典、白川昌宏、杤尾豪人
  • Industrial Property Rights Holder: 岐阜大学、京都大学
  • Filing Date: 2008-07-31
  • Overseas
• [Patent(Industrial Property Rights)] 変異導入MyD88蛋白によるToll様受容体/インターロイキーン18シグナルの特異的制御法 (2008)
  • Inventor(s): 近藤直実、加藤善一郎、大西秀典、白川昌宏、栃尾豪人
  • Industrial Property Rights Holder: 岐阜大学、京都大学
  • Filing Date: 2008-07-31
  • Overseas