| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
MyD88 is the important adaptor molecule in the Toll like receptors and IL-1/18 signaling pathways. In this study, we tried to create the molecule, which regulate these immune signaling response, based on the results of our decided protein structure of MyD88 and protein interaction studies. In the duration of this research aid, we could develop the several methods of direct protein-protein interaction studies with the TIR domain containing molecules. Furthermore, we created the new molecule, protein transduction domain containing dominant negative formed MyD88 (PTD-MyD88-DN). We will continue the drug development that assumed MyD88 a target.
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