Microarray analysis and development of a novel molecular targeted therapy for neurodegenerative lysosomal storage diseases.
| Project/Area Number |
20790728
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Tottori University |
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Principal Investigator |
HIGAKI Katsumi Tottori University, 生命機能研究支援センター, 准教授 (90294321)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ライソゾーム病 / 小児神経疾患 / 脂質代謝異常 / シグナル伝達 / マイクロアレイ / 疾患モデルマウス / 治療法開発 / 脳神経疾患 / 脂質 / シグナル伝逹 |
|---|
| Research Abstract |
GM1-gangliosidosis is a lysosomal lipid storage disorders. Microarray analysis using the brain of model mice revealed that expression levels of gene related to the intracellular protein degradation and inflammation was changed when compared to the normal mice. These data would be beneficial for the future development of a novel molecular targeted therapy for the brain pathology of this disease.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] A fluorescent sp2-iminosugar with pharmacological chaperone activity for Gaucher disease : Synthesis and intracellular distribution studies.2010
Author(s)
Luan Z, Higaki K, Aquilar-Moncayo M, Li L, Ninomiya H, Nanba E, Ohno K, Garcia-Moreno MI, Ortiz Mellet C, Garcia Fernandez JM, Suzuki Y1 :
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Journal Title
ChemBioChem 11
Pages: 2453-2463
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