Antitumor effect of bone marrow mesenchymal stem cell to Ewing sarcoma
| Project/Area Number |
20790729
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Okayama University |
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Principal Investigator |
MIYAMURA Takako Okayama University, 岡山大学病院, 助教 (20379796)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 移植・再生医療 / 間葉系幹細胞 / 細胞・組織 / 癌 |
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| Research Abstract |
It has been reported that mesenchymal stem cell(MSC) could induce apoptosis in various cancer cells. Moreover, MSC can target injured part. We planned to investigate about the following ; (1) Antitumor effect to Ewing sarcoma of normal MSC (2) Amplification of antitumor effect of anti-cancer drugs (including bisphosphonate) by coculture with MSC. It tended to obtain the higher anti-tumor effects to the Ewing sarcoma cell line by coculuture of MSC and anti-tumor agents. We evaluated the ability of MSC as the delivery vehicles of the anti-cancer drugs to achieve the higher antitumor effects, and it is necessary to continue a further research.
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Report
(4 results)
Research Products
(26 results)
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[Presentation] 小児がん学会2008
Author(s)
宮村能子、康勝好、石井栄一ほか
Organizer
乳児期発症の白血病について後方視的全国調査
Place of Presentation
千葉
Year and Date
2008-11-15
Related Report
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