| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
It has been reported that mesenchymal stem cell(MSC) could induce apoptosis in various cancer cells. Moreover, MSC can target injured part. We planned to investigate about the following ; (1) Antitumor effect to Ewing sarcoma of normal MSC (2) Amplification of antitumor effect of anti-cancer drugs (including bisphosphonate) by coculture with MSC. It tended to obtain the higher anti-tumor effects to the Ewing sarcoma cell line by coculuture of MSC and anti-tumor agents. We evaluated the ability of MSC as the delivery vehicles of the anti-cancer drugs to achieve the higher antitumor effects, and it is necessary to continue a further research.
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