| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Research Abstract |
To investigate the pathogenic mechanism of Diamond-Blackfan anemia (DBA), I have developed a zebrafish DBA model by knocking down the ribosomal protein s19 gene using morpholino antisense oligo. Translational efficiency or production of total proteins in this model seemed almost same as control embryos. However, they showed the defective maturation of erythroid lineage by 2-3 days post fertilization. This suggests that there is an unknown mechanism that affect translation of specific factors, especially those involved in the erythroid pathway.
|
