Development of the quantitative method and the analysis of function of the molecular marker for acute graft-versus-host disease.

• Project/Area Number: 20790735
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: Sapporo Medical University
• Principal Investigator: YAMAMOTO Masaki Sapporo Medical University, 医学部, 助教 (80404664)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 血液学 / 造血幹細胞移植 / 移植片対宿主病 / バイオマーカー / ケモカイン / GVHD / CCL8

Research Abstract

We studied about chemokine CCL8 as a biomarker of acute graft-versus-host disease (GVHD). We developed ELISA for plasma CCL8 level in the GVHD mouse models. We analyzed the expression mechanism of CCL8 using in vitro and in vivo model.

Research Products

• [Journal Article] Upregulation of plasma CCL8 in mouse model of graft-versus-host disease. (2009)
  • Author(s): Ota A, Yamamoto M, Hori T, Miyai S, Naishiro Y, Sohma H, Maeda M, Kokai Y
  • Journal Title: Exp. Hematol 2009 37(4) Pages: 523-531
  • Peer Reviewed
• [Journal Article] Upregulation of Plasma CCL8 in mouse model of graft-versus-host disease (2009)
  • Author(s): Ota A, et al.
  • Journal Title: Experimental Hematology 37 Pages: 525-531
  • Peer Reviewed
• [Presentation] CCL8 as a biomarker intimately associated with murine Graft-versus-host disease (GVHD) (2010)
  • Author(s): Yamamoto M, Ota A, Hori T, Imai S, Sohma H, Suzuki N, Hatakeyama N, Inazawa N, Tsutsumi H, Kokai Y
  • Organizer: 欧州骨髄移植学会
  • Place of Presentation: ウィーン
  • Year and Date: 2010-03-22
• [Presentation] CCL8 as a biomarker intimately associated with murine graft-versus-host disease (GVHD) (2010)
  • Author(s): Masaki Yamamoto, et al
  • Organizer: 第36回欧州骨髄移植学会(EBMT2010)
  • Place of Presentation: ウィーン(オーストリア)
  • Year and Date: 2010-03-22
• [Presentation] マウスモデルを用いたGVHDバイオマーカー候補CCL8の発現機序解析 (2009)
  • Author(s): 山本雅樹, 太田明伸、小海康夫、堀司、畠山直樹、鈴木信寛、堤裕幸
  • Organizer: 第71回日本血液学会総会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-24
• [Patent(Industrial Property Rights)] 宿主対移植片疾患の検査方法 (2009)
  • Inventor(s): 山本雅樹
  • Industrial Property Rights Holder: 札幌医科大学
  • Industrial Property Number: 2009-195951
  • Filing Date: 2009-08-26