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Molecular analyses of ER stress in childhood nephrotic syndrome

Research Project

Project/Area Number 20790740
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionWakayama Medical University

Principal Investigator

SHIMA Yuko  Wakayama Medical University, 医学部, 助教 (60433364)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsネフローゼ症候群 / 小胞体ストレス / シクロスポリン / ネフリン / 小胞体関連分解 / アポトーシス
Research Abstract

To clarify the presence of ER stress and a role of it in children with nephrotic syndrome, we obtained renal biopsy specimens in children with nephrotic syndrome. We performed real-time PCR to investigate the presence of ER stress and apoptosis. We analyzed EIF2α, GRP78, GRP94, CHOP and BAD. The amount of each gene amplification was examined before and after the administration of cyclosporine. The patients with cyclosporine showed significant increase of amplification of GRP78, GRP94, BAD, and EIF2α, suggesting that the use of cyclosporine is a factor provoking ER stress. The amplification of BAD increased significantly after the administration of cyclosporine, suggesting that the use of cyclosporine may induce apoptosis through ER stress.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (29 results)

All 2011 2010 2009 2008

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (18 results)

  • [Journal Article] Epithelial-to-mesenchymal transition in cyst lining epithelial cells in an orthologous PCK rat model of autosomal-recessive polycystic kidney disease.2011

    • Author(s)
      Togawa H, Nakanishi K, Mukaiyama H, Hama T, Shima Y, Sako M, Miyajima M, Nozu K, Nishii K, Nagao S, Takahashi H, Iijima K, Yoshikawa N.
    • Journal Title

      Am J Physiol Renal Physiol. 300(2)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disappearance of glomerular IgA deposits in childhood IgA nephropathy showing diffuse mesangial proliferation after 2 years of combination/prednisolone therapy.2011

    • Author(s)
      Shima Y, Nakanishi K, Kamei K, Togawa H, Nozu K, Tanaka R, Sasaki S, Iijima K, Yoshikawa N.
    • Journal Title

      Nephrol Dial Transplant. 26(1)

      Pages: 163-169

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disappearance of glomerular IgA deposits in childhood IgA nephropathy showing diffuse mesangial proliferation after 2 years of combination/prednisolone therapy.2011

    • Author(s)
      Yuko Shima
    • Journal Title

      Nephrolgy Dialysis Transplantation

      Volume: 26(1) Pages: 163-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial-to-mesenchymal transition in cyst lining epithelial cells in an orthologous PCK rat model of autosomal-recessive polycystic kidney disease.2011

    • Author(s)
      Hiroko Togawa, Yuko Shima
    • Journal Title

      American Journal of Physiology Renal Physiology

      Volume: 300(2) Pages: 511-20

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membranous nephropathy associated with thyroid-peroxidase antigen.2009

    • Author(s)
      Shima Y, Nakanishi K, Togawa H, Obana M, Sako M, Miyawaki M, Nozu K, Iijima K, Yoshikawa N.
    • Journal Title

      Pediatr Nephrol. 24(3)

      Pages: 605-608

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased chymase-positive mast cells in children with crescentic glomerulonephritis.2009

    • Author(s)
      Togawa H, Nakanishi K, Shima Y, Obana M, Sako M, Nozu K, Tanaka R, Iijima K, Yoshikawa N.
    • Journal Title

      Pediatr Nephrol. 24(5)

      Pages: 1071-1075

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased chymase-positive mast cells in children with crescentic glomerulonephritis.2009

    • Author(s)
      Hiroko Togawa, Yuko Shima
    • Journal Title

      Pediatric Nephrology 24

      Pages: 1071-1075

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] I Membranous Nephropathy associated with thyroid-peroxidase antigen2009

    • Author(s)
      Yuko Shima
    • Journal Title

      Pediatric Nephrology 24

      Pages: 605-608

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased chymase-positive mast cells in children with crescentic vlomerulonephritis2009

    • Author(s)
      Hiroko Togawa
    • Journal Title

      Pediatric Nephrology 24

      Pages: 1071-1075

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved renal survival in Japanese children with IgA nephropathy.2008

    • Author(s)
      Yata N, Nakanishi K, Shima Y, Togawa H, Obana M, Sako M, Nozu K, Tanaka R, Iijima K, Yoshikawa N.
    • Journal Title

      Pediatr Nephrol. 23(6)

      Pages: 905-912

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improved renal survival in Japanese children with IgA nephropathy2008

    • Author(s)
      Nahoko Yata
    • Journal Title

      Pediatric Nephrology 23

      Pages: 905-912

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Prognostic factors in childhood IgA nephropathy with focal mesangial proliferation treated with angiotensin converting enzyme inhibitors.2010

    • Author(s)
      Yuko Shima
    • Organizer
      43th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Denver, USA
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Natural remission rate and prognostic factors in childhood IgA Nephropathy with minimal change or focal mesangial proliferation.2010

    • Author(s)
      Yuko Shima
    • Organizer
      The 15^<th> congress of the International Pediatric Nephrology Association
    • Place of Presentation
      New York, USA
    • Year and Date
      2010-08-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prognostic factors in childhood IgA nephropathy with focal mesangial proliferation treated with angiotensin converting enzyme inhibitors.2010

    • Author(s)
      Shima Y, Nakanishi K, Togawa K, Mukaiyama H, Hama T, Nozu K, Tanaka R, Iijima K, Yoshikawa N
    • Organizer
      43rd Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Denver, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Natural remission rate and prognostic factors in childhood IgA nephropathy with minimal change or focal mesangial proliferation.2010

    • Author(s)
      Shima Y, Nakanishi K, Togawa H, Nozu K, Tanaka R, Iijima R, Yoshikawa K
    • Organizer
      15th Congress of the International Pediatric Nephrology Association
    • Place of Presentation
      New York, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] 微小変化・巣状メサンギウム増殖を示す小児IgA腎症における自然寛解率とその予測因子2010

    • Author(s)
      島友子、中西浩一、戸川寛子、野津寛大、飯島一誠、田中亮二郎、吉川徳茂
    • Organizer
      第45回小児腎臓病学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 運動後急性腎不全とPRESの合併を反復し、GLUT9遺伝子複合ヘテロ接合体変異を同定しえた腎性低尿酸血症の一例2010

    • Author(s)
      島友子、野津寛大、戸川寛子、貝藤裕史、飯島一誠、松尾雅文、中西浩一、吉川徳茂
    • Organizer
      第45回小児腎臓病学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Factors for proteinuria disappearance after 2-yr combination/prednisolone therapy in severe childhood IgA nephropathy.2010

    • Author(s)
      Shima Y, Nakanishi K, Kamei K, Togawa H, Nozu K, Tanaka R, Sasaki S, Iijima K, Yoshikawa N
    • Organizer
      International Society of Nephrology NEXUS Symposium
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] 和歌山県立医大における取り組み2009

    • Author(s)
      島友子
    • Organizer
      第39回日本腎臓病学会西部学術集会
    • Place of Presentation
      県立文化会館(和歌山県)
    • Year and Date
      2009-10-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 重症小児IgA腎症における治療後腎IgA沈着消失の臨床病理学的意義2009

    • Author(s)
      島友子
    • Organizer
      第52回日本腎臓病学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Snaill Is Involved in Epithelial-to-Mesenchymal Transition (EMT) in Cyst-Lining Epithelial.2009

    • Author(s)
      Togawa H, Nakanishi K, Shima Y, Sako M, Miyajima M, Nozu K, Iijima K, Yoshihara D, Nagao S, Yoshikawa N
    • Organizer
      42^<nd> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] 運動後急性腎不全とPRES(Posterior reversible encephalopathy syndrome)の合併を反復した腎性低尿酸血症の1例2009

    • Author(s)
      島友子、中西浩一、戸川寛子、野津寛大、飯島一誠、吉川徳茂
    • Organizer
      第31回小児腎不全学会
    • Place of Presentation
      新潟
    • Related Report
      2010 Final Research Report
  • [Presentation] 和歌山県立医大における取り組み2009

    • Author(s)
      島友子、吉川徳茂、畑埜義雄
    • Organizer
      第39回日本腎臓病学会西部学術集会男女共同参画特別企画
    • Place of Presentation
      和歌山
    • Related Report
      2010 Final Research Report
  • [Presentation] 重症小児IgA腎症における治療反応性規定因子2009

    • Author(s)
      島友子、中西浩一、戸川寛子、尾鼻美奈、野津寛大、飯島一誠、田中亮二郎、佐々木聡、吉川徳茂
    • Organizer
      第44回小児腎臓病学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 重症小児IgA腎症における治療後腎IgA沈着消失の臨床病理学的意義2009

    • Author(s)
      島友子、中西浩一、戸川寛子、尾鼻美奈、野津寛大、田中亮二郎、佐々木聡、飯島一誠、吉川徳茂
    • Organizer
      第52回日本腎臓病学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Disappearance of glomerular IgA deposits in severe IgA nephropathy after 2-yr of combination/predonisolone therapy2008

    • Author(s)
      Yuko Shima
    • Organizer
      The 41th Annual Meeting of the American Society of Nephrologv
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Disappearance of glomerular IgA deposits in severe childhood IgA nephropathy after 2-yr combination/predonisolone therapy.2008

    • Author(s)
      Shima Y, Nakanishi K, Togawa H, Obana M, Nozu K, Tanaka R, Sasaki S, Iijima K, Yoshikawa N.
    • Organizer
      J Am Soc Nephrol, 2008 41^<st> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] 運動後急陛腎不全(ALPE)を呈しPRES(Posterior Reversible Encephalopathy Syndrome)を合併した腎性低尿酸血症の一例2008

    • Author(s)
      島友子、中西浩一、渋田昌一、戸川寛子、尾鼻美奈、野津寛大、貝藤裕史、飯島一誠、吉川徳茂
    • Organizer
      第30回日本小児腎不全学会学術集会
    • Place of Presentation
      栃木
    • Related Report
      2010 Final Research Report
  • [Presentation] IgA沈着が消失した重症型小児IgA腎症26例の検討2008

    • Author(s)
      島友子、中西浩一、戸川寛子、尾鼻美奈、野津寛大、田中亮二郎、佐々木聡、飯島一誠、吉川徳茂
    • Organizer
      第43回日本小児腎臓病学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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