Analysis of heme oxygenase-1 in secondary hemophagocytic syndrome

• Project/Area Number: 20790741
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: Wakayama Medical University
• Principal Investigator: YOSHIYAMA Megumi Wakayama Medical University, 医学部, 助教 (00433368)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 小児血液学 / 血球貪食症候群 / ヘムオキシゲナーゼ-1 / 遺伝子多型 / 予後因子 / 二次性血球貪食症候群 / HO-1

Research Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening conditions characterized by uncontrolled activation of T-cells and macrophages. The precise mechanism leading to the development of immune response dysregulation resulting in hypercytokinemia has not been well evaluated. We speculated that heme oxygenase-1 might be involved in the abnormal immune reactions in acquired HLH. Serum levels of heme oxygenase-1 were elevated in HLH patients and our results suggest that heme oxygenase-1 might be a useful bio-marker of HLH.

Research Products

• [Journal Article] Cytotoxic T-Lymphocyte-associated antigen 4 gene polymorphisms in Japanese children with infection-associated hemophagocytic lymphohistiocytosis. (2010)
  • Author(s): Megumi Yoshiyama, Shinji Kounami, Keiko Nakayama, Takahiro Okutani, Noriyuki Aoyagi, Norishige Yoshikawa.
  • Journal Title: Acta Haematol 123 Pages: 186-190
  • Peer Reviewed
• [Journal Article] CTLA-4 gene polymorphisms in Japanese children with infection-associated hemophagocytic lymphohistiocytosis. (2010)
  • Author(s): Yoshiyama M, Kounami S, et al.
  • Journal Title: Acta Haematologica Volume: 123 Pages: 186-190
  • Peer Reviewed
• [Journal Article] 血小板減少性紫斑病が診断契機となったcommon variable immunodeficiencyの6歳男児例 (2009)
  • Author(s): 神波信次、中山京子、芳山恵、吉川徳茂、岩橋誠司、末永智浩
  • Journal Title: 小児内科 41(6) Pages: 951-954
  • Peer Reviewed
• [Journal Article] Clinical assessment of Mycoplasma pneumoniae-associated hemophagocytic lymphohistiocytosis. (2008)
  • Author(s): Megumi Yoshiyama, Shinji Kounami, Keiko Nakayama, Noriyuki Aoyagi, Norishige Yoshikawa.
  • Journal Title: Ped Int 50 Pages: 432-435
  • NAID: 10025344099
  • Peer Reviewed
• [Journal Article] 急性リンパ性白血病維持療法中に発症したPneumocystis pneumoniaeの3症例 (2008)
  • Author(s): 神波信次, 中山京子, 芳山恵, 吉川徳茂
  • Journal Title: 日本小児血液学会誌 22(5/6) Pages: 360-365
  • Peer Reviewed
• [Journal Article] Clinical assessment of Mycoplasma pneumoniae-associated hem oohaaocvtic lvmohohistiocvtosis (2008)
  • Author(s): Yoshiyama M
  • Journal Title: Pediatr Int. 50(4) Pages: 432-5
  • Peer Reviewed
• [Journal Article] Cytotoxic T lymphocyte-associated antigen 4 gene polymorphisms in Japanese children with infection-associated hemophagocytic_lymphohistiocytosis.
  • Author(s): Yoshiyama M
  • Journal Title: Acta Haematologica (in press)
  • Peer Reviewed
• [Presentation] CTLA-4遺伝子多型は小児感染症関連血球貪食症候群に関与する (2009)
  • Author(s): 芳山恵, 神波信次, 中山京子, 吉川徳茂
  • Organizer: 日本血液学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-11-24