Establishment of treatment strategy for rodents with afterloaded right ventricle dysfunction by using physilogic analysis.

• Project/Area Number: 20790751
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: Jikei University School of Medicine
• Principal Investigator: URASHIMA Takashi Jikei University School of Medicine, 医学部, 助教 (20338875)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 右心不全 / ラット / 小児 / 肺動脈絞扼術

Research Abstract

To evaluate progression of afterloaded right ventricle (RV) remodeling, molecular and physiologic examination were performed in a murine model of pulmonary artery stenosis. Afterloaded RV was showing a dilatation of camber and fibrosis compared with afterloaded left ventricle (LV). Pro-collagen was elevated in afterloaded RV not LV by using RT-PCR. These results suggested that treatment fibrosis in RV is useful to prevent decompensated RV heart failure.

Research Products

• [Journal Article] Yang Multimodality Evaluation of the Viability of Stem Cells Delivered Into Different Zones of Myocardial Infarction (2008)
  • Author(s): Ta-Chuan Hung, Yoriyasu Suzuki, Takashi Urashima, Anthony Caffarelli, Grant Hoyt, Ahmad Y. Sheikh, Alan C. Yeung, Irving Weissman, Robert C. Robbins, Jeff M. Bulte, Phillip C
  • Journal Title: Circ Cardiovasc Imaging 1(1) Pages: 6-13
  • Peer Reviewed
• [Journal Article] Molecular and physiological characterization of RV remodeling in amurinemodel of pulmonary stenosis (2008)
  • Author(s): Takashi Urashima, et.al.
  • Journal Title: Am J Physiol Heart Circ Physiolo 295
  • Peer Reviewed
• [Presentation] Characters of Right Heart Failure Model Mouse and the Differe ntial Gene Expression in the AfterloadStressed Right vs Left Ventricle (2009)
  • Author(s): 浦島崇
  • Organizer: 第73回日本循環器学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-03-22
• [Presentation] 小動物用CTを用いた肺血管床の定量化 (2009)
  • Author(s): 浦島崇、小川潔、斉藤亮太、安藤達也、藤原優子、中澤誠、井田博幸
  • Organizer: 第45回日本小児循環器学会
  • Place of Presentation: 神戸
• [Presentation] 外科的に作成した右心不全モデルラットに対するPV loopを用いた左右心機能 (2009)
  • Author(s): 浦島崇、小川潔、斉藤亮太、安藤達也、藤原優子、中澤誠、井田博幸
  • Organizer: 第112回日本小児科学会
  • Place of Presentation: 奈良
• [Presentation] 外科的右心不全モデルマウスにおける右室肥大の生理学的 (2008)
  • Author(s): 浦島崇、Daniel Bernstein, 飯島正紀、斉藤亮太、安藤達也、藤原優子、中澤誠、衛藤義勝
  • Organizer: 分子生物学的特徴第43回日本小児循環器学会学術集会
  • Place of Presentation: 郡山
• [Presentation] Daniel Bernstein Molecular and physiologic characteristics of right heart failure. (2008)
  • Author(s): 浦島崇、小川潔
  • Organizer: 第43回日本小児循環器学会学術集会シンポジウム
  • Place of Presentation: 郡山