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Dynamic analysis of the Nox family NADPH oxidases in the pathogenesis of Kawasaki disease

Research Project

Project/Area Number 20790761
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionNational Research Institute for Child Health and Development

Principal Investigator

MORIYA Mie  National Research Institute for Child Health and Development, 母児感染研究部, 共同研究員 (60470001)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords川崎病 / 循環器 / Nox / 酸化ストレス / TNF-α / 冠動脈瘤 / NADPH oxidase / 血管内皮細胞 / 活性酸素 / 好中球 / 血管外遊出
Research Abstract

Potentiated generation of reactive oxygen spices (ROS) from neutrophil Nox2 by TNF-α was reported to contribute to ICAM-1 expression in vascular endothelial cells (VEC), which plays a key role in neutrophil extravasation and following aneurysm formation. However, this possibility was only concluded by indirect studies using reducing agents or inhibitors against Nox. In order to get a definite answer, we produced a mouse model of Kawasaki disease using LCWE, and then inspected it with Nox2-KO mice. The inspection studies clearly demonstrated that TNF-α induces ICAM-1 expression, directly affecting VEC without the aid of ROS from neutrophil Nox2.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (4 results)

All 2009 Other

All Presentation (2 results) Remarks (2 results)

  • [Presentation] Dynamic analysis of the Nox family NADPH oxidases in the pathogenesis of Kawasaki disease.2009

    • Author(s)
      綱脇祥子、内田友祐、吉田ルシア幸子、守屋美恵
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] Is the neutrophil NADPH oxidase (Nox2) involved in the pathogenesis of Kawasaki disease?2009

    • Author(s)
      守屋美恵、吉田ルシア幸子、綱脇祥子
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.ncchd.go.jp/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.ncchd.go.jp/

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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