Relation between abnormalities of serotonergic neurons and anxiety-related behaviors on prenatally ethanol-exposed rats
| Project/Area Number |
20790766
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
OHTA Kenichi The University of Tokushima, 大学院・ヘルスバイオサイエンス研究室, 助教 (50403720)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | 胎生期エタノール曝露 / セロトニン / 不安様行動 / 先天異常学 / 胎生期アルコール曝露 / 不安・恐怖 / 高架式T字迷路試験 / 高架式プラットホーム試験 / 中脳縫線核 |
|---|
| Research Abstract |
We investigated the serotonergic system and anxiety-related behavior of rats prenatally exposed to ethanol. Anxiety-related behavior tests revealed that the susceptibility to anxiety was decreased in prenatally ethanol-exposed rats. However, their innate fears were facilitated only when they were exposed to intensive aversive stimuli. The abnormalities of anxiety-related behaviors might be attributed to the depressed serotonergic action as a result of a reduced number of serotonergic cells in the midbrain raphe nuclei or the abnormal fluctuation in brain serotonin during development.
|
Report
(3 results)
Research Products
(8 results)
