Project/Area Number |
20790767
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Embryonic/Neonatal medicine
|
Research Institution | The University of Tokushima |
Principal Investigator |
SAKATA Hiromi The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 講師 (50294666)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 脳発達障害 / コレステロール / セロトニン / ドーパミン / 不安様行動 / Shh |
Research Abstract |
We examined the role of cholesterol and serotonin in prenatal brain development. A moderate level of cholesterol deficiency during the prenatal period did not affect development of the serotonergic and dopaminergic systems in rat fetuses. However, rats exposed to a inhibitor of an enzyme for serotonin synthesis showed a increased reactivity to conditioned fear during an elevated T-maze behavioral test. Prenatal brain serotonin might affect the sensitivities to adverse stimuli after birth.
|