| Project/Area Number |
20790767
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SAKATA Hiromi The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 講師 (50294666)
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|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 脳発達障害 / コレステロール / セロトニン / ドーパミン / 不安様行動 / Shh |
|---|
| Research Abstract |
We examined the role of cholesterol and serotonin in prenatal brain development. A moderate level of cholesterol deficiency during the prenatal period did not affect development of the serotonergic and dopaminergic systems in rat fetuses. However, rats exposed to a inhibitor of an enzyme for serotonin synthesis showed a increased reactivity to conditioned fear during an elevated T-maze behavioral test. Prenatal brain serotonin might affect the sensitivities to adverse stimuli after birth.
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