Project/Area Number |
20790770
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Embryonic/Neonatal medicine
|
Research Institution | Fukushima Medical University |
Principal Investigator |
TAKAHASHI Hidenori Fukushima Medical University, 医学部, 助教 (70347227)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 胎児医学 / 子宮内プログラミング / 成人病胎児発症起源 / 子宮内胎児プログラミング / iNOS / 制御生T細胞 / 炎症 / 妊娠期母体栄養 / 成人病胎児起源説 / 高血圧 / 成人病胎児期起源説 / 生活習慣病 / 母体栄養 / 小児期高血圧 |
Research Abstract |
Maternal high fat environment make a hypertensive offspring, but regulation of fat feeding during lactation period may reduce adulthood hypertension. In case with normal food, restrictive feeding during late gestation is more effective than lactation period for inducing hypertensive male offspring. Regulation of maternal feeding not only during late gestation but also lactation period may control adulthood hypertension. Fetal origin of adult hypertension might be vascular endothelial dysfunction. Inflammatory responses in F1 female mice are similar to the uterine environment in production of NOx. Therefore, a maternally-derived iNOS mutation is important in inflammatory responses of aged females respectively.
|