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Evaluation of Adrenal Function in Preterm Infants by Liquid Chromatography Tandem Mass Spectrometry based Serum Steroids Assay

Research Project

Project/Area Number 20790772
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Embryonic/Neonatal medicine
Research InstitutionKeio University

Principal Investigator

MIWA Masayuki  慶應義塾大学, 医学部, 助教 (30383855)

Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords副腎機能 / 胎児副腎 / 早産児 / 超低出生体重児 / タンデム質量分析
Research Abstract

Fetal and adult adrenal glands markedly different to morphological and endocrinological. Therefore, accurate evaluation of adrenal function in neonate especially preterm infants is difficult. We measured serum steroids profile using liquid chromatography tandem mass spectrometry (LC/MSMS). That is the most reliable method to evaluate neonatal adrenal function. Result showed pattern of steroid secretory after birth was the same for term and preterm infants. Additionally 170Hpregnenolone and 170HP increased with younger gestational age, whereas cortisol was a small difference. To conclude, adrenal function is low in preterm infants.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (19 results)

All 2012 2011 2010 2009 2008

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (15 results) Book (3 results)

  • [Journal Article] Late-onset Circulatory Collapse in Very Low-birthweight Infants : A Japanese Perspective2009

    • Author(s)
      Masayuki Miwa, Satoshi Kusuda, Kazushige Ikeda
    • Journal Title

      NeoReviews 2009

      Volume: 10

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 副腎の発達正期産児と早産児2012

    • Author(s)
      三輪雅之
    • Organizer
      第2回名古屋新生児成長発達研究会
    • Place of Presentation
      愛知県・名古屋国際センタービル
    • Year and Date
      2012-01-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 副腎の発達正期産児と早産児2012

    • Author(s)
      三輪雅之
    • Organizer
      第2回名古屋新生児成長発達研究会
    • Place of Presentation
      愛知県名古屋国際センタービル(招待講演)
    • Year and Date
      2012-01-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 早産児の血中アルドステロン濃度比較2011

    • Author(s)
      三輪雅之
    • Organizer
      第56回日本未熟児新生児学会
    • Place of Presentation
      東京都・東京国際フォーラム
    • Year and Date
      2011-11-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 早産児の血中アルドステロン濃度比較2011

    • Author(s)
      三輪雅之
    • Organizer
      第56回日本未熟児新生児学会
    • Place of Presentation
      東京都東京国際フォーラム
    • Year and Date
      2011-11-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新生児血中ステロイド一斉測定による週数別・AGA新生児副腎機能比較2011

    • Author(s)
      三輪雅之
    • Organizer
      第47回周産期・新生児学会
    • Place of Presentation
      北海道・札幌コンベンションセンター
    • Year and Date
      2011-07-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 新生児血中ステロイド一斉測定による週数別・AGA新生児副腎機能比較2011

    • Author(s)
      三輪雅之
    • Organizer
      第47回日本周産期・新生児医学会
    • Place of Presentation
      北海道札幌コンベンションセンター
    • Year and Date
      2011-07-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 正期産児および早産児における出生後血中ステロイドホルモン変化の比較2010

    • Author(s)
      三輪雅之
    • Organizer
      第46回周産期・新生児学会
    • Place of Presentation
      兵庫県・神戸国際会議場
    • Year and Date
      2010-07-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 正期産児および早産児における出生後血中ステロイドホルモン変化の比較2010

    • Author(s)
      三輪雅之
    • Organizer
      第46回周産期新生児学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-07-13
    • Related Report
      2010 Annual Research Report 2010 Self-evaluation Report
  • [Presentation] 30週以下の早産児における出生後早期の血中ステロイドホルモン変化2009

    • Author(s)
      三輪雅之
    • Organizer
      第45回周産期・新生児学会
    • Place of Presentation
      愛知県・名古屋国際会議場
    • Year and Date
      2009-07-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 30週以下の早産児における出生後早期の血中ステロイドホルモン変化2009

    • Author(s)
      三輪雅之
    • Organizer
      第45回周産期新生児学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-07-14
    • Related Report
      2010 Self-evaluation Report 2009 Annual Research Report
  • [Presentation] Serum Steroid Profile in Newborn : Comparison between Term and Preterm Infant by Using Liquid Chromatography Tandem Mass Spectrometry2008

    • Author(s)
      三輪雅之
    • Organizer
      第49回European Society of Paediatric Research
    • Place of Presentation
      フランス
    • Year and Date
      2008-10-26
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] SERUM STEROID PROFILE IN NEWBORN : COMPARISON BETWEEN TERM AND PRETERM INFANT BY USING LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY/MASS SPECTROMETRY2008

    • Author(s)
      三輪雅之
    • Organizer
      49回European Society for Paediatric Research
    • Place of Presentation
      フランス
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Serum Steroid Profile in Newborn : Comparison between Term and Preterm Infant by Using Liquid Chromatography/Mass Spectrometry/Mass Spectrometry2008

    • Author(s)
      Masayuki Miwa
    • Organizer
      49^<th> European Society for Paediatric Research
    • Place of Presentation
      France, Nice
    • Year and Date
      2008-10-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 血中ステロイドホルモン一斉測定による早産AGA・SGA児の副腎機能評価2008

    • Author(s)
      三輪雅之
    • Organizer
      第44回周産期新生児学会
    • Place of Presentation
      横浜
    • Year and Date
      2008-07-14
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 血中ステロイドホルモン一斉測定による早産SGA・SGA児の副腎機能評価2008

    • Author(s)
      三輪雅之
    • Organizer
      第44回周産期新生児学会
    • Place of Presentation
      横浜
    • Year and Date
      2008-07-14
    • Related Report
      2008 Annual Research Report
  • [Book] 新生児内分泌ハンドブック2008

    • Author(s)
      三輪雅之
    • Publisher
      メディカ出版
    • Related Report
      2011 Final Research Report
  • [Book] 新生児内分泌ハンドブック(新生児期副腎皮質機能の評価方法)(編集 河井昌彦)2008

    • Author(s)
      三輪雅之
    • Publisher
      メディカ出版
    • Related Report
      2010 Self-evaluation Report
  • [Book] 新生児内分泌ハンドブック(新生児期副腎皮質機能の評価方法)2008

    • Author(s)
      三輪雅之(編集河井昌彦)
    • Publisher
      メディカ出版
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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