Analysis of PDA pathogenesis with novel PDA model mice.

• Project/Area Number: 20790775
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Chubu University
• Principal Investigator: YAJIMA Ichiro Chubu University, 生命健康科学研究所, 研究員 (80469022)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 色素細胞学 / 循環器学 / 発生学 / 腫瘍学 / 色素細胞 / メラノサイト / 動脈管開存症 / メラニン

Research Abstract

Tyr : : Cre ; ss-catFloxedEx3 mice were generated by crossing Tyr : : Cre transgenic mice with ss-catFloxedEx3 mice. These mice showed PDA by enhanced activity of ss-catenin after birth. In these mice, ectopic melanocytes were localized in the heart and they directly and/or indirectly affect formation of the PDA.

Research Products

• [Journal Article] A novel mouse model for de novo melanoma. (2010)
  • Author(s): Kumasaka M, Yajima I, Hossain K, Iida M, Tsuzuki T, Ohno T, Takahashi M, Yanagisawa, M, Kato M.
  • Journal Title: Cancer Res. 70(1) Pages: 24-9
  • Peer Reviewed
• [Journal Article] CD109 expression levels in malignant melanoma. (2010)
  • Author(s): Ohshima Y, Yajima I, Kumasaka MY, Yanagishita T, Watanabe D, Takahashi M, Inoue Y, Ihn H, Matsumoto Y, Kato M.
  • Journal Title: J Dermatol Sci. 57(2) Pages: 140-2
  • NAID: 10027399745
  • Peer Reviewed
• [Journal Article] CD109 expression levels in malignant melanoma (2010)
  • Author(s): Yuichiro Ohshia
  • Journal Title: Journal of Dermatological Science 57 Pages: 140-142
  • Peer Reviewed
• [Journal Article] A novel mouse model for de novo melanoma (2010)
  • Author(s): Mayuko Kumasaka
  • Journal Title: Cancer research 70 Pages: 24-29
  • Peer Reviewed
• [Journal Article] Toxic Elements in Well Water from Malaysia (2010)
  • Author(s): Masashi Kato
  • Journal Title: Toxicol Environ Chem (In press)
  • Peer Reviewed
• [Journal Article] Zinc finger protein 28 as a novel melanoma-related molecule. (2009)
  • Author(s): Yajima I, Kumasaka M, Thang ND, Yanagishita T, Ohgami N, Kallenberg D, Naito Y, Yoshikawa T, Sakashita N, Kato M.
  • Journal Title: J Dermatol Sci. 55(1) Pages: 68-70
  • NAID: 10025334344
  • Peer Reviewed
• [Journal Article] The tyrosinase promoter is active in a subset of vagal neural crest cells during early development in mice. (2009)
  • Author(s): Puig I, Yajima I, Bonaventure J, Delmas V, Larue L.
  • Journal Title: Pigment Cell Melanoma Res. 22(3) Pages: 331-4
  • Peer Reviewed
• [Journal Article] Mitf functions as an in ovo regulator for cell differentiation and proliferation during development of the chick RPE. (2009)
  • Author(s): Tsukiji N, Nishihara D, Yajima I, Takeda K, Shibahara S, Yamamoto H.
  • Journal Title: Dev Biol. 15,326(2) Pages: 335-46
  • Peer Reviewed
• [Journal Article] Zinc finger protein 28 as a novel melanoma-related molecule (2009)
  • Author(s): Ichiro Yajima
  • Journal Title: Journal of Dermatological Science 55 Pages: 68-70
  • NAID: 10025334344
  • Peer Reviewed
• [Journal Article] Zinc finger protein 28 as a novel melanoma-related molecule (2009)
  • Author(s): Ichiro Yaiima
  • Journal Title: Journal of Dermatological Science (In press)
  • Peer Reviewed
• [Journal Article] The location of heart melanocytes is specified and the level of pigmentation in the heart may correlate with coat color. (2008)
  • Author(s): Yajima I, Larue L.
  • Journal Title: Pigment Cell Melanoma Res. 21(4) Pages: 471-6
  • Peer Reviewed
• [Presentation] モデルマウスを用いた、紫外線による悪性黒色腫の発症リスク解析とリスクファクター遺伝子の探索 (2009)
  • Author(s): 矢嶋伊知朗
  • Organizer: 日本衛生学会第78回大会
  • Place of Presentation: 東京(北里大学)
  • Year and Date: 2009-03-30
• [Presentation] Classicalmelanocyteとnon-classicalmelanocyteの役割一心臓メラノサイトと心疾患の関連性一 (2008)
  • Author(s): 矢嶋伊知朗
  • Organizer: 日本動物学会第79回大会
  • Place of Presentation: 福岡(福岡大学)
  • Year and Date: 2008-09-05
• [Book] 生物の科学遺伝 ヒトの皮膚・眼の色の遺伝学 (2009)
  • Author(s): 矢嶋伊知朗、熊坂真由子
  • Publisher: 株式会社エヌ・ティー・エス
• [Book] 生物の科学・遺伝 (2009)
  • Author(s): 山本博章
  • Publisher: (株)エヌ・ティー・エス