Mechanism of Ductus arteriosus through an endogenous inhibitor of NOS

• Project/Area Number: 20790778
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kurume University
• Principal Investigator: KAJIMOTO Hidemi Kurume University, 循環器病研究所, 助教 (50349700)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 新生児医学 / 動脈管 / 血管内皮 / 一酸化窒素 / 遺伝子

Research Abstract

Dimethylarginine dimethylaminohydrolase that metabolizes endogenous NOS inhibitor increases after ductus arteriosus closure. Analysis of the comprehensive gene expression profile changes provided new insight into understanding the mechanism of DA closure.

Research Products

• [Journal Article] 慢性腎不全患者の心血管病変進展における内因性NO合成阻害物質(ADMA)の役割 (2009)
  • Author(s): 梶本英美、甲斐久史、今泉勉
  • Journal Title: 腎臓 32(2) Pages: 103-107
• [Journal Article] Large blood pressure variability and hypertensive cardiac remodeling-role of cardiac inflammation (2009)
  • Author(s): Kai H, Kudo H, Takayama N, Yasuoka S, Kajimoto H, Imaizumi T
  • Journal Title: Circ J 73(12) Pages: 2198-2203
  • NAID: 10025937956
  • Peer Reviewed
• [Journal Article] Exaggerated blood pressure variability superimposed on hypertension aggravates cardiac remodeling in rats via angiotensin II system-mediated chronic inflammation (2009)
  • Author(s): Kudo H, Kai H, Kajimoto H, Koga M, Takayama N, Mori T, Ikeda A, Yasuoka S, Anegawa T, Mifune H, Kato S, Hirooka Y, Imaizumi T
  • Journal Title: Hypertension 54(4) Pages: 832-838
  • Peer Reviewed
• [Journal Article] Increased P-selectin expression on platelets and decreased plasma thrombomodulin in patients after the Fontan procedure (2009)
  • Author(s): Kajimoto H, Nakazawa M, Murasaki K, Hagiwara N, Nakanishi T
  • Journal Title: Circ. J 73(9) Pages: 1705-1710
  • Peer Reviewed
• [Journal Article] Developmental absence of the O2 sensitivity of L-type calcium channels in preterm ductus arteriosus smooth muscle cells impairs O2 constriction contributing to patent ductus arteriosus (2008)
  • Author(s): Thebaud B, Wu XC, Kajimoto H, Bonnet S, Hashimoto K, Michelakis ED, Archer SL
  • Journal Title: Pediatr Res 63(2) Pages: 176-181
  • Peer Reviewed
• [Journal Article] Developmental absence of the O2 sensitivity of L-type calcium channels in preterm ductus arteriosus smooth muscle cells impairs O2 constriction contributing to patent ductus arteriosus (2008)
  • Author(s): Thebaud B, Wu XC, Kajimoto H(他4名3番目)
  • Journal Title: Pediatr Res 63 Pages: 176-181
  • Peer Reviewed
• [Presentation] 腎不全における血清Asymmetric Dimethylarginineの上昇が血管内皮に与える影響 (2010)
  • Author(s): Kajimoto H, Kai H, Yasuoka S, Anegawa T, Imaizumi T
  • Organizer: 6th Cardiovascular Translational Research
  • Place of Presentation: Conference, Fukuoka
  • Year and Date: 2010-02-13
• [Presentation] Comprehensive Analysis of the Gene Expression Profile Changes Before and After Ductus Arteriosus Closure in Rats (2010)
  • Author(s): Kajimoto H, Kai H, Miyamoto T, Imaizumi T
  • Organizer: 74th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Kyoto, Japan
• [Presentation] Smad-Msx2 Pathway Plays an Initial Role in Vascular Calcification in CKD Mice (2010)
  • Author(s): Kajimoto H, Kai H, Yasuoka S, Anegawa T, Imaizumi T
  • Organizer: 74th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Kyoto, Japan
• [Presentation] Eplerenone Prevented the Large Blood Pressure Variability-Induced Aggravation of Perivascular Inflammation and Cardiac Remodeling in Spontaneously Hypertensive Rats (2010)
  • Author(s): Yasuoka S, Kai H, Kajimoto H, Kudoh H, Takayama N, Anegawa T, Imaizumi T
  • Organizer: 74th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Kyoto, Japan
• [Presentation] Comprehensive Analysis of the Gene Expression Profile Changes Before and After Ductus Arteriosus Closure in Rats (2010)
  • Author(s): Kajimoto Hidemi
  • Organizer: 第74回日本循環器学会学術集会
  • Place of Presentation: 京都
• [Presentation] Asymmetric Dimethylarginine Triggers Vasculo-Renal Interaction in CKD Mice: Circulation 120 (18): S1077 (2009)
  • Author(s): Kajimoto H, Kai H, Yasuoka S, Anegawa T, Aoki H, Imaizumi T
  • Organizer: American Heart Association's Scientific Sessions
  • Place of Presentation: Orlando, USA
• [Presentation] Enhanced cardiac inflammation and myocardial fibrosis in ovariectomized, pressure-overloaded rats -A possible mechanism of aggravation of diastolic dysfunction in the post-menopause: Circulation (2009)
  • Author(s): Mori H, Kai H, Kajimoto H, Kudo H, Takayama N, Ikeda A, Yasuoka S, Anegawa T, Imaizumi T
  • Organizer: American Heart Association's Scientific Sessions
  • Place of Presentation: Orlando, USA
• [Presentation] 腎不全マウスにおける血清Asymmetric Dimethylarginineの上昇が血管内皮に与える影響 (2009)
  • Author(s): Kajimoto H, Kai H, Yasuoka S, Aoki H, Anegawa T, Imaizumi T
  • Organizer: The 32nd Annual Scientific Meeting of the Japanese Society of Hypertension
  • Place of Presentation: Shiga, Japan
• [Presentation] Asymmetric Dimethylarginine is a paracrine regulator of vascular function in CKD (2009)
  • Author(s): Kajimoto H, Kai H, Yasuoka S, Aoki H, Anegawa T, Imaizumi T
  • Organizer: The 13th Annual Scientific Meeting of the Japanese Heart Failure Society
  • Place of Presentation: Fukuoka, Japan
• [Presentation] 血清Asymmetric Dimethylargininの増加が腎不全マウスにおける内皮機能障害を起こす (2009)
  • Author(s): Kajimoto H, Kai H, Yasuoka S, Aoki H, Anegawa T, Imaizumi T
  • Organizer: The 57th Annual Scientific Session of the Japanese College of Cardiology
  • Place of Presentation: Sapporo, Japan
• [Presentation] Asymmetric Dimethylarginine Induces Endothelial Dysfunction in Renal Failure Mice (2009)
  • Author(s): Kajimoto H, Kai H, Yasuoka S, Ikeda, A, Imaizumi T
  • Organizer: 73rd Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Osaka, Japan
• [Presentation] Asymmetric Dimethylarginine induces endothelial dysfunction in renal failuremice (2009)
  • Author(s): Kajimoto Hidemi
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Selective collection and comprehensive gene expression analysis of eachtissue comnonent of the heart using microdissection method (2009)
  • Author(s): Ikeda A, et.al.(他5名4番目)
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Role of Asymmetric Dimethylarginine in Endothelial Dysfunction in Renal Failure Mice (2008)
  • Author(s): Kajimoto H, Kai H, Yasuoka S, Ikeda, A, Imaizumi T
  • Organizer: 62nd High Blood Pressure Research Conference
  • Place of Presentation: Atlanta, USA
• [Presentation] レーザーマイクロダイセクション法を用いた心筋構成細胞の選択的遺伝子発現解析法の開発 (2008)
  • Author(s): 池田理望(他4名4番目)
  • Organizer: 第30回日本高血圧学会
  • Place of Presentation: 札幌