regulation of hyaluronan production by keratinocytes

• Project/Area Number: 20790783
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Tohoku University
• Principal Investigator: OHTANI Tomoyuki Tohoku University, 病院, 助教 (20400319)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ヒアルロン酸 / HABP / spongisis / spongiosis / 培養ヒト角化細胞 / HAS3

Research Abstract

The staining of HABP was enhanced in spongiosis. IL-4, IL-13, and IFN-・increased the hyaluronan production and enhanced the HAS3 mRNA expression by NHEK. Hyaluronan accumulation in the spongiotic epidermis was surrounded by keratinocytes.

Research Products

• [Journal Article] Increased hyaluronan production and decreased E-cadherin expression by cytokine-stimulated keratinocytes lead to spongiosis formation. (2009)
  • Author(s): Ohtani T, et al
  • Journal Title: J Invest Dermatol 129 Pages: 1412-1420
  • Peer Reviewed
• [Journal Article] Increased byaluronan production and decreased E-cadherin expression by cytokine-stimulated keratioocytes lead to spongiosis formation (2009)
  • Author(s): Ohtani T, ほか
  • Journal Title: I Invest Dermatol (In press)
  • Peer Reviewed
• [Journal Article] Molecular events in human T cells treated with diesel exhaust particles or formaldehyde that underlie their diminished interferon-eamma and interleukin-10 production (2009)
  • Author(s): Sasaki Y, Ohtani, ほか
  • Journal Title: Int Arch Allergy Immunol 148 Pages: 239-250
  • Peer Reviewed
• [Journal Article] TGF-betal dampens the susceptibility of dendritic cells to environmental stimulation, leading to the requirement for danger signals for activation (2009)
  • Author(s): Ohtani T, ほか
  • Journal Title: Immunology 126 Pages: 485-499
  • Peer Reviewed
• [Presentation] 表皮におけるヒアルロン酸合成とE-cadherin発現の制御-海綿状態皮膚ではヒアルロン酸合成が増強しE-cadherin発現が低下する- (2008)
  • Author(s): 大谷朋之, ほか
  • Organizer: 第38回日本皮膚アレルギー・接触皮膚炎学会総会・学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2008-11-08