Analysis of the mechanism for dendritic cell maturation by haptens

• Project/Area Number: 20790785
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Tohoku University
• Principal Investigator: MIZUASHI Masato Tohoku University, 病院, 助教 (20400369)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 樹状細胞 / ハプテン / チオール基 / ER stress / 血小板 / CD40 ligand / 樹上細胞

Research Abstract

In this study, we examined whether sensitizers oxidize cell surface thiols of monocyte-derived dendritic cells (MoDCs). All the sensitizers that we examined decreased cell surface thiols on MoDCs. Our data suggest that the oxidation of cell surface thiols have some role in triggering DC maturation by sensitizers. In addition, we also suggest that both ER stress and CD40 ligand derived from platelets are related to DC maturation by sensitizers.

Research Products

• [Journal Article] Oxidation of Cell Surface Thiol Groups by Contact Sensitizers Triggers the Maturation of Dendritic Cells. (2010)
  • Author(s): Kagatani S, Sasaki Y, Hirota M, Mizuashi M, Suzuki M, Ohtani T, Itagaki H, Aiba S.
  • Journal Title: J Invest Dermatol 130(1) Pages: 175-183
  • Peer Reviewed
• [Journal Article] Oxidation of cell surface thiol groups by contact sensitizers triggers the maturation of dendritic cells (2010)
  • Author(s): Kagatani S, Mizuashi M, et al.
  • Journal Title: Journal of Investigative Dermatology 130(1) Pages: 175-183
  • Peer Reviewed
• [Journal Article] Molecular events in human T cells treated with diesel exhaust particles or formaldehyde that underlie their diminished interferon-gamma and interleukin-10 production (2009)
  • Author(s): Sasaki Y, Ohtani T, Ito Y, Mizuashi M, Nakagawa S, Furukawa T, Horii A, Aiba S.
  • Journal Title: Int Arch Allergy Immunol 148(3) Pages: 239-250
  • Peer Reviewed
• [Journal Article] TGF-〓l dampens the susceptibility of dendritic cells to environmental stimulation, leading to the requirement for danger signals for activation (2009)
  • Author(s): Ohtani T, Mizuashi M, Nakagawa S, Sasaki Y, Fujimura T, Okuyama R, Aiba S.
  • Journal Title: Immunology 126 Pages: 485-499
  • Peer Reviewed