TLR4 and its signaling pathways on melanoma cells may be a potential direct target for immuno- and molecular therapy in melanoma patients.

• Project/Area Number: 20790794
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Shinshu University
• Principal Investigator: GOTO Yasufumi Shinshu University, 医学部附属病院, 助教(特定雇用) (60467181)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 皮膚腫瘍学 / 皮膚腫瘍 / メラノーマ / Toll様受容体 / 分子標的薬 / 皮膚科学 / 腫瘍免疫学

Research Abstract

TLR activation of tumor cells is suggested to be a factor promoting tumor progression in melanoma. TLR4 and its signaling pathways on melanoma cells may be a potential direct target for molecular therapy in melanoma patients.

Research Products

• [Journal Article] Cancer Cells Expressing Toll-like Receptors and the Tumor Microenvironment. (2009)
  • Author(s): Sato Y, Goto Y, et al.
  • Journal Title: Cancer Microenviron 2Suppl1 Pages: 205-14
  • Peer Reviewed
• [Journal Article] Cancer Cells Expressing Toll-like Receptors and the Tumor Microenvironment (2009)
  • Author(s): Sato Y, Goto Y, Narita N, Hoon DS.
  • Journal Title: Cancer Microenviron 2 Suppl 1 Pages: 205-214
  • Peer Reviewed
• [Journal Article] Activation of toll-like receptors 2, 3, and 4 on human melanoma cells induces inflammatory factors. (2008)
  • Author(s): Goto Y, Arigami T, Kitago M, et al.
  • Journal Title: Mol Cancer Ther. Nov;7(11) Pages: 3642-53
  • Peer Reviewed
• [Journal Article] Activation of toll-like receptors 2, 3, and 4 on human melanoma cells induces inflammatory factors (2008)
  • Author(s): 後藤康文
  • Journal Title: Molecular Cancer Therapeutics 7 Pages: 3642-53
  • Peer Reviewed
• [Presentation] The activation of Toll-Like Receptor 4 on human melanoma cells induced cell proliferation and migration (2009)
  • Author(s): Yasufumi Goto, Yukiko Kiniwa, Kaori Sakaizawa, Jingrong Lin, Aya Uchiyama, Minoru Takata
  • Organizer: 第34回日本研究皮膚科学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-12-04
• [Presentation] (2009)
  • Organizer: 第34回日本研究皮膚科学会総会
  • Place of Presentation: 福岡
• [Presentation] (2009)
  • Organizer: 7th World Congress on Melanom
  • Place of Presentation: ウィーン
• [Presentation] (2009)
  • Organizer: 第108回皮膚科学会総会
  • Place of Presentation: 福岡
• [Presentation] Activation of Toll-like Receptors on Human Melanoma Cells (2008)
  • Author(s): 後藤康文
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] (2008)
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
• [Presentation] (2008)
  • Organizer: 東京皮膚フォーラム
  • Place of Presentation: 東京
• [Remarks]
  • URL: http://www.shinshu-u.ac.jp/faculty/medicine/chair/i-hifu/index.html