Analysis of lipid metabolic pathway activated by ganglioside in human melanoma cells and its application to melanoma therapy
Project/Area Number |
20790796
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Dermatology
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Research Institution | Nagoya University |
Principal Investigator |
YAMAUCHI Yoshio Nagoya University, 大学院・医学系研究科, 助教 (00444878)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | メラノーマ / ガングリオシド / 脂質代謝 / Aktシグナル / SREBP / Akt / コレステロール |
Research Abstract |
Plasma membrane microdomains plays crucial roles in malignant properties of various cancer cells. Metabolism of cholesterol, an essential component of the microdomains, and its role in malignant phenotype of melanoma cells were investigated. The results show that Akt signaling serves as a molecular switch to
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] GM1/GD1b/GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line.2010
Author(s)
Dong Y., Ikeda K., Hamamura K., Zhang Q., Kondo Y., Matsumoto Y., Ohmi Y., Yamauchi Y., Furukawa K., Taguchi R., Furukawa K.
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Journal Title
NAID
Related Report
Peer Reviewed
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