Molecular analysis of mechanisms regulating drug sensitivity of lymphoid neoplasms to HDAC inhibitor
| Project/Area Number |
20790802
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Okayama University |
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Principal Investigator |
FUJII Kazuyasu Okayama University, 岡山大学病院, 助教 (70452571)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | HDAC阻害剤 / 薬剤感受性 / ヒストン脱アセチル化酵素阻害剤 / プロテオーム / 2D-DIGE / HDAC阻害薬 / バルプロ酸 / NK細胞 |
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| Research Abstract |
To elucidate the molecular mechanisms and the predictive markers of sensitivity to histone deacetylase inhibitor (HDACi), we compared with IC50 values for valproic acid, one of the HDACi, in 37 lymphoid cell lines and their 2D-DIGE expression profiles. We newly identified 19 protein spots associated with HDACi sensitivity.
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Report
(3 results)
Research Products
(27 results)
