The mechanism analysis of immune suppression by ultraviolet

• Project/Area Number: 20790809
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Nagoya City University
• Principal Investigator: SHINTANI Yoichi Nagoya City University, 大学院・医学研究科, 研究員 (10336688)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: UVA1 / Narrow-band UVB / 免疫抑制 / 制御性T細胞 / 紫外線 / 免疫学 / 光医学

Research Abstract

Narrow-band UVB and UVA1 is used more often to treat refractory skin diseases. We have tested whether narrow-band and UVA1 have a capacity to induce immune suppression. Narrow-band UVB suppressed delayed-type hypersensitivity (DTH) and contact hypersensitivity by inducing the production of antigen-specific regulatory T cells. The ultraviolet wavelength that induces regulatory T cells to DTH, however, was not known. A monochromator was used to irradiate a mouse DTH model using several UVB wavelengths (290nm, 300nm, 310nm, and 320nm). All the wavelengths tested significantly suppressed DTH, with 310nm inducing peak immune suppression. UVA1 also induced immune suppression without antigen specificity, indicating the mechanisms might be different from narrow-band induced immune suppression.

Research Products

• [Journal Article] ナローバンドUVBによる奏効機序-免疫抑制 (2011)
  • Author(s): 新谷洋一
  • Journal Title: Monthly Book Derma 172巻 Pages: 5-9
• [Journal Article] Tobacco smoke is related to Th17 generation with clinical implications for psoriasis patients (2011)
  • Author(s): Torii K, Saito C, Furuhashi T, Nishioka A, Shintani Y, Kawashima K, Kato H, Morita A
  • Journal Title: Exp Dermatol 20巻 Pages: 371-373
  • Peer Reviewed
• [Journal Article] ナローバンドUVBによる奏効機序-免疫抑制 (2011)
  • Author(s): 新谷洋一
  • Journal Title: Monthly Book Derma Volume: 172 Pages: 5-9
  • Peer Reviewed
• [Journal Article] Tobacco smoke is related to Th17 generation with clinical implications for psoriasis patients (2011)
  • Author(s): Kan Torii, Chiyo Saito, Takuya Furuhashi, Akiko Nishioka, Yoichi Shintani, Kana Kawashima, Hiroshi Kato, Akimichi Morita
  • Journal Title: Exp Dermatol Volume: 20 Pages: 371-373
  • Peer Reviewed
• [Journal Article] UVB wavelength dependency of antimicrobial peptide induction for innate immunity in normal human keratinocytes (2009)
  • Author(s): Torii K, Maeda A, Saito C, Furuhashi T, Shintani Y, Shirakata Y, Morita A
  • Journal Title: J Dermatol Sci 56巻 Pages: 217-219
  • NAID: 10027398979
  • Peer Reviewed
• [Journal Article] Feasibility and accuracy of a newly developed hand-held device with a flat-type fluorescent lamp for measuring the minimal erythema dose for narrow-band UVB therapy (2009)
  • Author(s): Morita A, Shintani Y, Nishida E, Kato H, Yoshida H, Minamoto M, Yamaguchi Y, Maeda A
  • Journal Title: Photodermatol Photoimmunol Photomed 25巻 Pages: 41-44
  • Peer Reviewed
• [Journal Article] The development of a filter to enhance the efficacy and safety of excimer light (308nm) therapyPhotodermatol (2009)
  • Author(s): Kobayashi K, Yasuda Y, Shintani Y, Sumitomo T, Saga T, Kimura M, Yamamoto A, Mori T, Maeda A, Yamaguchi Y, Morita A
  • Journal Title: Photoimmunol Photomed 25巻 Pages: 30-36
  • Peer Reviewed
• [Journal Article] UVB wavelength dependency of antimicrobial peptide induction for innate immunity in mormal human keratinocytes (2009)
  • Author(s): Torii K, Macda A, Saito C, Furuhashi T, Shintani Y, Shirakata Y, Morita A
  • Journal Title: J Dermatol Sci. 56(3) Pages: 217-219
  • Peer Reviewed
• [Journal Article] Feasibility and accuracy of a newly developed hand-held device with a flat-type fluorescent lamp for measuring the minimal erythema dose for narrow-band UVB therapy (2009)
  • Author(s): Akimichi Morita
  • Journal Title: Photodermatol Photoimmunol Photomed 25(1) Pages: 41-44
  • Peer Reviewed
• [Journal Article] The development of a filter to enhance the efficacy and safety of excim er light(308nm) therapy (2009)
  • Author(s): Keiko Kobayashi
  • Journal Title: Photodermatol Photoimmunol Photomed 25(1) Pages: 30-36
  • Peer Reviewed
• [Presentation] 光の標的と臨床:光に対する免疫応答 (2010)
  • Author(s): 新谷洋一
  • Organizer: 第22回レーザー治療学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-06-26
• [Presentation] 光の標的と臨床:光に対する免疫応答 (2010)
  • Author(s): 新谷洋一
  • Organizer: 第22回レーザー治療学会
  • Place of Presentation: 横浜(横浜シンポジア)
  • Year and Date: 2010-06-26
• [Presentation] High-dose UVA1 in combination with narrow-band UVB irradiation completely suppresses UVB-induced Langerhans cell migration and diminishes UVB-induced tolerance (2010)
  • Author(s): Shintan Y
  • Organizer: 70th Society for Investigative Dermatology
  • Place of Presentation: Atlanta, US
  • Year and Date: 2010-05-07
• [Presentation] High-dose UVA1 in combination with narrow-band UVB irradiation completely suppresses UVB-induced Langerhans cell migration and diminishes UVB-induced tolerance. (2010)
  • Author(s): Yoichi Shintani
  • Organizer: 70^<th> Society for Investigative Dermatology
  • Place of Presentation: Atlanta, US (Hilton Atlanta)
  • Year and Date: 2010-05-07
• [Presentation] UVA1 irradiation diminishes UVB-induced tolerance via inhibition of langerhans cell migration (2009)
  • Author(s): Shintani Y
  • Organizer: 日本研究皮膚科学会 第34回年次学術大会・総会
  • Place of Presentation: 福岡
  • Year and Date: 2009-12-04
• [Presentation] UVA1 irradiation diminishes UVB-induced tolerance iva inhibition of langerhans cell migration (2009)
  • Author(s): Yoichi Shintani
  • Organizer: 日本研究皮膚科学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-12-04
• [Presentation] 繰り返しUVA1照射による接触過敏反応・遅延型過敏反応の抑制効果 (2009)
  • Author(s): 新谷洋一
  • Organizer: 光医学光生物学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-24
• [Presentation] UVA1照射の接触過敏反応・遅延型過敏反応への影響 (2009)
  • Author(s): 新谷洋一
  • Organizer: UV-ABClub-38
  • Place of Presentation: 愛知
  • Year and Date: 2009-02-28
• [Presentation] UVAI照射の接触過敏反応・遅延型過敏反応への影響 (2009)
  • Author(s): 新谷洋一
  • Organizer: UV-ABCIub-38
  • Place of Presentation: 愛知
  • Year and Date: 2009-02-28
• [Presentation] High-dose UVA1 radiation induces FoxP3+ regulatory T cells, but does not affect delayed type hypersensitivity (2008)
  • Author(s): Shintani Y
  • Organizer: 5th International Investigative Dermatology 2008
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2008-05-17