| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Narrow-band UVB and UVA1 is used more often to treat refractory skin diseases. We have tested whether narrow-band and UVA1 have a capacity to induce immune suppression. Narrow-band UVB suppressed delayed-type hypersensitivity (DTH) and contact hypersensitivity by inducing the production of antigen-specific regulatory T cells. The ultraviolet wavelength that induces regulatory T cells to DTH, however, was not known. A monochromator was used to irradiate a mouse DTH model using several UVB wavelengths (290nm, 300nm, 310nm, and 320nm). All the wavelengths tested significantly suppressed DTH, with 310nm inducing peak immune suppression. UVA1 also induced immune suppression without antigen specificity, indicating the mechanisms might be different from narrow-band induced immune suppression.
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