A basic study of next generate varicella zoster virus vaccine

• Project/Area Number: 20790820
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Jikei University School of Medicine
• Principal Investigator: ITO Hideki Jikei University School of Medicine, 医学部, 講師 (70360138)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 水痘 / 帯状疱疹 / 水痘帯状疱疹ワクチン / 次世代ワクチン / 水痘帯状疱疹ウイルス / ワクチン / 水痘ワクチン

Research Abstract

ORF39 gene of VZV is essential for replication of VZV. We tried to insert a unique AvrII site which is located between ORF65 and ORF66, however, no virus is replicated. We guess the location of VZV gene ORF39 is important for replication of VVZ.