| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
ss-catenin is associated with white spotting induced by abnormal migration of melanoblasts and melanocytes. Among ECMs, fibronectin is suggested to be involved in this phenotype. On fibronectin, melanocytes from the white spot model mice migrate slower than those from wild-type mice. Changes of orientation of F-actin and the associated signaling in this white spot mice are responsible for this phenotype.
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